MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy.
MicroRNAs and Chinese Medicinal Herbs: New Possibilities in Cancer Therapy.
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DOI：
10.3390/cancers7030855
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发表时间：
2015-08-24
期刊：
影响因子：
5.2
通讯作者：
Feng Y
中科院分区：
文献类型：
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作者：
Hong M;Wang N;Tan HY;Tsao SW;Feng Y
近几十年来，中医药在世界范围内被用作治疗癌症的补充和替代医学。大量研究表明，microRNAs（miRNAs）在包括肿瘤在内的多种病理过程中发挥着重要作用，同时针对miRNAs的中药抗癌机制也得到了广泛的探讨。本课题组及其他研究人员在多种肿瘤模型中对中草药及miRNAs的研究为肿瘤治疗提供了新的可能性，如上调miR-23 a的表达可能激活p53和miR-23 a的正调控网络，参与小檗碱抗肝癌作用的机制。本文综述了中草药制剂在调节miRNAs在肿瘤中的作用以及介导miRNAs在肿瘤治疗中的应用。此外，还讨论了草药来源的外源性miRNAs在癌症治疗中的争议作用。靶向miRNA有望通过改善癌症治疗的总体应答和生存结局，特别是当与常规疗法和中草药产品组合时，为癌症治疗提供新的治疗方法。
In recent decades Chinese medicine has been used worldwide as a complementary and alternative medicine to treat cancer. Plenty of studies have shown that microRNAs (miRNAs) play fundamental roles in many pathological processes, including cancer, while the anti-cancer mechanisms of Chinese medicinal herbs targeting miRNAs also have been extensively explored. Our previous studies and those of others on Chinese medicinal herbs and miRNAs in various cancer models have provided a possibility of new cancer therapies, for example, up-regulating the expression of miR-23a may activate the positive regulatory network of p53 and miR-23a involved in the mechanism underlying the anti-tumor effect of berberine in hepatocellular carcinoma (HCC). In this review, we survey the role of Chinese medicinal herbal products in regulating miRNAs in cancer and the use of mediating miRNAs for cancer treatment. In addition, the controversial roles of herb-derived exogenous miRNAs in cancer treatment are also discussed. It is expected that targeting miRNAs would provide a novel therapeutic approach in cancer therapy by improving overall response and survival outcomes in cancer treatment, especially when combined with conventional therapeutics and Chinese medicinal herbal products.