Preparation of monodisperse water-in-oil emulsions using microchannel homogenization
Preparation of monodisperse water-in-oil emulsions using microchannel homogenization
复制标题
利用微通道均质化制备单分散油包水乳液
DOI：
10.1080/02726351.2022.2160852
复制
发表时间：
2022
影响因子：
2.5
通讯作者：
Nakajima Mitsutoshi
中科院分区：
文献类型：
--
作者：
Li Ran;Kobayashi Isao;Zhang Yanru;Neves Marcos A.;Uemura Kunihiko;Nakajima Mitsutoshi
油包水（W/O）乳液的液滴尺寸和均匀性是决定其在不同应用中的稳定性的重要性质。单分散乳液优于多分散乳液，因为它们的液滴尺寸和分布更容易控制。在这里，我们制备（相对）单分散W/O乳液使用微通道均化（MCH）与非对称直通微通道（MC）阵列芯片。在绝缘体上硅芯片上微制造了许多非对称直通MC，每个MC包括微槽和圆形微孔（直径：10 µm）。我们研究了乳化剂浓度、连续相粘度、分散相体积分数和粗W/O乳液的操作压力对W/O乳液的制备、液滴尺寸和尺寸分布的影响。连续相由大豆油或中链甘油三酯油溶液与蓖麻油酸缩合单月桂酸四甘油酯作为乳化剂组成。分散相是含有NaCl和/或聚乙二醇（m.w. 20，000）。结果表明，MCH适用于制备单分散W/O乳液，平均液滴直径为12-15 µm，变异系数最低为8%，使用疏水表面处理的不对称直通MC，适当选择乳液组成和操作条件。
The droplet size and uniformity of water-in-oil (W/O) emulsions are important properties governing their stability in diverse applications. Monodisperse emulsions are preferred over polydisperse emulsions because their droplet size and distribution are easier to control. Here, we prepared (relatively) monodisperse W/O emulsions using microchannel homogenization (MCH) with an asymmetric straight-through microchannel (MC) array chip. Numerous asymmetric straight-through MCs, each comprising a microslot and circular microhole (diameter: 10 µm), were microfabricated on a silicon-on-insulator chip. We investigated the effects of emulsifier concentration, continuous-phase viscosity, dispersed-phase volume fraction, and the operating pressure of coarse W/O emulsions on the preparation of W/O emulsions, droplet size, and size distribution. The continuous phase was composed of soybean or medium-chain triglyceride oil solutions with tetraglycerin monolaurate condensed ricinoleic acid ester as the emulsifier. The dispersed phase was a Milli-Q water solution containing NaCl and/or polyethylene glycol (m.w. 20,000). The results demonstrate the suitability of MCH for the preparation of monodisperse W/O emulsions with an average droplet diameter of 12–15 µm and 8% lowest coefficient of variation using hydrophobically surface-treated asymmetric straight-through MCs with appropriately selected emulsion compositions and operating conditions.