Rhodamine-based fluorogenic probe for imaging biological thiol
Rhodamine-based fluorogenic probe for imaging biological thiol
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DOI：
10.1016/j.bmcl.2008.03.014
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发表时间：
2008-04-01
影响因子：
2.7
通讯作者：
Ito, Yoshihiro
中科院分区：
文献类型：
--
作者：
Shibata, Aya;Furukawa, Kazuhiro;Ito, Yoshihiro
我们研制了一种新的生物巯基荧光探针。该探针是由modi. 2，4-二硝基苯磺酰基与罗丹明110的阳离子。在生物条件下实现了巯基物质如半胱氨酸或谷胱甘肽的选择性检测。此外，该探针被成功地应用于在活的人类细胞中的巯基物种的成像。(C)2008爱思唯尔有限公司保留所有权利。
We have developed a new fluorescent probe for biological thiol. The probe was synthesized by the modi. cation of the 2,4-dinitrobenzenesulfonyl group with rhodamine 110. The selective detection of thiol species such as cysteine or glutathione was achieved in biological conditions. Moreover, the probe was successfully applied to the imaging of thiol species in living human cells. (C) 2008 Elsevier Ltd. All rights reserved.