In Vivo Cortical Tau in Parkinson's Disease Using 18F-AV-1451 Positron Emission Tomography
In Vivo Cortical Tau in Parkinson's Disease Using 18F-AV-1451 Positron Emission Tomography
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DOI：
10.1002/mds.26961
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发表时间：
2017-06-01
影响因子：
8.6
通讯作者：
Borghammer, Per
中科院分区：
文献类型：
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作者：
Hansen, Allan K.;Damholdt, Malene Flensborg;Borghammer, Per
背景：阿尔茨海默病的共同病理学是常见的PD在尸检。在患有轻度认知障碍的非PD受试者中，可以使用18F-AV-1451 PET检测tau沉积。我们假设18F-AV-1451 PET将显示PD患者中的tau蛋白聚集并伴有轻度认知功能障碍，并与认知功能障碍相关。目的：描述PD患者中的tau蛋白聚集。方法：26例PD患者和23例对照者进行了18F-AV-1451 PET和神经心理学评估，以检测轻度认知功能障碍。结果：9例PD患者（35%）被确定为轻度认知功能障碍。区域分析显示，各组之间没有显著差异。逐体素分析显示与患者内的认知域Z分数无相关性。结论：18F-AV-1451检测到的tau蛋白异常在伴有轻度认知功能障碍的PD患者中并不常见，且与该阶段的认知功能障碍无明显相关性。(C)2017国际帕金森和运动障碍协会
Background: Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.Objectives: To describe tau aggregation in PD patients.Methods: Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment.Results: Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.Conclusion: Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. (C) 2017 International Parkinson and Movement Disorder Society