Intestinal macrophages - specialised adaptation to a unique environment
Intestinal macrophages - specialised adaptation to a unique environment
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DOI：
10.1002/eji.201141714
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发表时间：
2011-09-01
影响因子：
5.4
通讯作者：
Mowat, Allan McI
中科院分区：
文献类型：
--
作者：
Bain, Calum C.;Mowat, Allan McI
近年来，人们对肠道单核吞噬细胞 (MP)、DC 和巨噬细胞 (M phi s) 的兴趣激增。在本观点中，我们将详细介绍常驻肠固有层 (LP) M phi 如何拥有反映对独特微环境的适应的独特特性。它们在正常和发炎的粘膜中发挥着完全不同的作用，并且正如我们将要展示的，分化的 M phi 子集以及基于其他组织的“常驻”与“炎症”单核细胞的现有范例可能不适用于肠道。针对 M phi 作为抑制肠道炎症的手段的策略需要考虑到这些独特的特征。
Interest in intestinal mononuclear phagocytes (MPs), both DCs and macrophages (M phi s), has exploded in the recent years. In this Viewpoint we will detail how resident intestinal lamina propria (LP) M phi s possess distinctive properties that reflect adaptation to a unique microenvironment. They play quite different roles in the normal and inflamed mucosa and, as we will show, the existing paradigms of differentiated M phi subsets and of 'resident' versus 'inflammatory' monocytes based on other tissues may not apply to the gut. Strategies for targeting M phi s as a means of dampening intestinal inflammation will need to take account of these unique characteristics.