The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease
The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease
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DOI：
10.1016/j.bbadis.2018.08.025
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发表时间：
2019-04-01
影响因子：
6.2
通讯作者：
Rehling, Peter
中科院分区：
文献类型：
--
作者：
Dudek, Jan;Hartmann, Magnus;Rehling, Peter
线粒体在心脏的能量代谢中起重要作用。许多基本功能与呼吸链驱动的线粒体膜和氧化磷酸化有关。线粒体膜在细胞中是独特的，因为它们含有磷脂心磷脂。心磷脂在心血管健康中的重要作用通过几种心脏疾病突出，其中心磷脂起着根本性作用。Barth综合征、Syndrome综合征和扩张型心肌病伴共济失调（DCMA）是影响心磷脂生物合成的遗传性疾病。其他心血管疾病，包括缺血/再灌注损伤和心力衰竭也与心磷脂库的变化有关。本文综述了心磷脂在线粒体生物发生和形态学中的分子功能。我们强调心磷脂的呼吸链，代谢物载体，线粒体代谢的作用，并描述与细胞凋亡和线粒体特异性自噬（线粒体自噬）与心脏疾病的可能影响的联系。
Mitochondria play an essential role in the energy metabolism of the heart. Many of the essential functions are associated with mitochondrial membranes and oxidative phosphorylation driven by the respiratory chain. Mitochondrial membranes are unique in the cell as they contain the phospholipid cardiolipin. The important role of cardiolipin in cardiovascular health is highlighted by several cardiac diseases, in which cardiolipin plays a fundamental role. Barth syndrome, Sengers syndrome, and Dilated cardiomyopathy with ataxia (DCMA) are genetic disorders, which affect cardiolipin biosynthesis. Other cardiovascular diseases including ischemia/reperfusion injury and heart failure are also associated with changes in the cardiolipin pool. Here, we summarize molecular functions of cardiolipin in mitochondrial biogenesis and morphology. We highlight the role of cardiolipin for the respiratory chain, metabolite carriers, and mitochondrial metabolism and describe links to apoptosis and mitochondria specific autophagy (mitophagy) with possible implications in cardiac disease.