Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.
Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.
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DOI：
10.1007/s00360-016-1029-6
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Duff RJ
中科院分区：
文献类型：
--
作者：
Ball HC;Londraville RL;Prokop JW;George JC;Suydam RS;Vinyard C;Thewissen JG;Duff RJ
脂质沉积和利用的过程中，通过基因瘦素（Lep），知之甚少的类群不同程度的脂肪储存。这项研究探讨了这些系统如何适应鲸类动物居住的海洋水生环境。北极露脊鲸（Balaena mysticetus）和白鲸（Delphinapterus leucas）是理想的研究动物-它们拥有大量的皮下脂肪储存（鲸脂），并在食物供应变化的同时进行两年一次的迁徙。为了回答长期存在的问题，关于如何（或如果）能源和脂质利用适应水生压力，我们量化的基因转录的变化与季节，年龄和鲸脂深度相关的脂质代谢至关重要。我们预测了瘦素的三级结构保守性，并评估了弓头鲸和其他哺乳动物之间Lep转录本数量的种间差异。我们的研究是第一个确定这些鲸目动物中Lep和脂解的季节性和年龄相关变化。虽然Lep转录物和蛋白质在成年弓头鲸中随着季节而波动，让人想起冬眠的哺乳动物，但弓头鲸的转录水平比任何其他哺乳动物高出10倍。来自未成熟弓头鲸的数据与短须鲸抑制有效摄食的假设一致。脂解成绩单也表明年轻的秋季弓头鲸和那些在春季几个月的采样限制能量利用。这些来自很少检查的物种的新数据扩展了现有的知识，并提供了对Lep和脂解调节如何适应季节性沉积和维持重要脂肪储存的独特见解。
The processes of lipid deposition and utilization, via the gene leptin (Lep), are poorly understood in taxa with varying degrees of adipose storage. This study examines how these systems may have adapted in marine aquatic environments inhabited by cetaceans. Bowhead (Balaena mysticetus) and beluga whales (Delphinapterus leucas) are ideal study animals- they possess large subcutaneous adipose stores (blubber) and undergo bi-annual migrations concurrent with variations in food availability. To answer long-standing questions regarding how (or if) energy and lipid utilization adapted to aquatic stressors, we quantified variations in gene transcripts critical to lipid metabolism related to season, age and blubber depth. We predicted Leptin tertiary structure conservation and assessed inter-specific variations in Lep transcript numbers between bowheads and other mammals. Our study is the first to identify seasonal and age-related variations in Lep and lipolysis in these cetaceans. While Lep transcripts and protein oscillate with season in adult bowheads reminiscent of hibernating mammals, transcript levels reach up to 10-times higher in bowheads than any other mammal. Data from immature bowheads are consistent with the hypothesis that short baleen inhibits efficient feeding. Lipolysis transcripts also indicate young Fall bowheads and those sampled during Spring months limit energy utilization. These novel data from rarely examined species expand existing knowledge and offer unique insight into how the regulation of Lep and lipolysis has adapted to permit seasonal deposition and maintain vital blubber stores.
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影响因子：
2.8
作者：
Dunkin, RC;McLellan, WA;Pabst, DA
通讯作者：
Pabst, DA
DOI：
10.1139/z75-159
发表时间：
1975-01-01
期刊：
CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE
影响因子：
--
作者：
ACKMAN, RG;HINGLEY, JH;ODENSE, PH
通讯作者：
ODENSE, PH
影响因子：
1.7
作者：
AGUILAR, A;BORRELL, A
通讯作者：
BORRELL, A
DOI：
10.1073/pnas.0507519103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Crespi, Erica J.;Denver, Robert J.
通讯作者：
Denver, Robert J.
影响因子：
3.5
作者：
Bustin, SA
通讯作者：
Bustin, SA