Modulation of symptomatic palatal tremor by magnetic stimulation of the motor cortex.
Modulation of symptomatic palatal tremor by magnetic stimulation of the motor cortex.
复制标题
通过运动皮层的磁刺激调节症状性腭震。
DOI：
10.1016/s1388-2457(00)00301-1
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Liao,KK
中科院分区：
文献类型：
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作者：
Chen,JT;Yu,HY;Wu,ZA;Kao,KP;Hallett,M;Liao,KK
目的磁刺激运动皮层可用于确定节律性运动障碍的皮层参与。症状性腭震颤（SPT）被认为是来自起搏器，这是相对抵抗内部和外部刺激。在这项研究中，我们探讨了磁刺激运动皮层对SPT的影响。MethodsFive男性患者，年龄67-79岁，与SPT后脑干梗死或出血，都有一个同步的口角抽搐与腭运动。采用单极针电极记录口轮匝肌的肌电活动。实验1以200%运动阈值（MT）经颅磁刺激（TMS）复位SPT。在实验2中，研究了两名SPT患者在80- 240%MT下TMS强度的影响。为了确定TMS的影响，我们使用复位指数（RI）。结果TMS复位震颤在所有5个SPT患者在200%MT与RI为0.86-0.96。经颅磁刺激后震颤再现的潜伏期较刺激前震颤间隔延长，且随后的震颤爆发之间的间隔也延长。震颤复位的程度与磁刺激强度及经颅磁刺激后震颤再现的潜伏期密切相关。结论刺激运动皮层可调节SPT的发生。
ObjectivesMagnetic stimulation of the motor cortex can be used to determine the involvement of the cortex in rhythmic movement disorders. Symptomatic palatal tremor (SPT) is thought to come from a pacemaker that is relatively resistant to internal and external stimulation. In this study, we investigated the effect of magnetic stimulation of motor cortex on SPT.MethodsFive male patients, aged 67–79 years, with SPT after brain stem infarction or hemorrhage, all had a synchronous mouth angle twitch with the palatal movement. Electromyographic activity was recorded with a monopolar needle electrode from orbicularis oris. In experiment 1, transcranial magnetic stimulation (TMS) was delivered at 200% motor threshold (MT) to reset SPT. In experiment 2, the effect of TMS intensities was studied at 80–240% MT in two SPT patients. To determine the influence of the TMS, we used the resetting index (RI).ResultsTMS reset the tremor in all 5 SPT patients at 200% MT with RIs of 0.86–0.96. The latency of the tremor reappearance after TMS was longer than the pre-stimulus tremor interval, and the intervals between the subsequent tremor bursts were also prolonged. The degree of tremor resetting was closely correlated with the magnetic stimulus intensity and the latency of the tremor reappearance after TMS.ConclusionsStimulation of the motor cortex may modulate the generator of SPT.