Composition of dietary fat affects blood pressure and insulin responses to dietary obesity in the dog.
Composition of dietary fat affects blood pressure and insulin responses to dietary obesity in the dog.
复制标题
膳食脂肪的成分会影响狗的血压和胰岛素对膳食肥胖的反应。
DOI：
10.1002/j.1550-8528.1998.tb00328.x
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
West,DB
中科院分区：
文献类型：
--
作者：
Truett,AA;Borne,AT;Monteiro,MP;West,DB
在15只雌性绝育犬中评价了它们在饱和脂肪（LD，猪油，n=8）或不饱和脂肪（CO，玉米油，n=7）饮食变得肥胖之前和之后的心血管和代谢参数。两组的体重和体脂均显著增加，但饮食组之间无差异。接受LD饮食的狗比接受CO饮食的狗表现出更大的平均动脉压增加（p<0. 05）。01; 15. 9 ± 2。一对九。8 ± 3。3 mm Hg升高）。CO饮食比LD饮食刺激更大的心率增加（p<0. 05）。05; 32. 8 ± 7。八对十四。1 ± 5。8 bpm增加）。神经节阻滞与氯异松达明引起的增加，在这两个瘦组和肥胖的CO组，但不是肥胖的LD组，与减少副交感神经紧张的心脏在狗过度喂养饱和脂肪。在LD组中，肥胖增强了对异丙肾上腺素β-肾上腺素能刺激的心率反应，但CO组没有。LD饮食增加了循环胰岛素，降低了胰岛素敏感性，而CO饮食对这两个参数都没有影响。这些结果表明，膳食脂肪的组成可以调节饮食性肥胖诱导的自主神经和代谢适应。
Cardiovascular and metabolic parameters were evaluated in 15 female spayed dogs before and after they became obese on either a saturated fat (LD, lard, n=8) or unsaturated fat (CO, corn oil, n=7) diet. Body weight and body fat increased significantly in both groups, although no differences occurred between diet groups. Dogs receiving the LD diet exhibited a greater increase in mean arterial pressure than those receiving the CO diet (p<0. 01; 15. 9 ± 2. 1 vs. 9. 8 ± 3. 3 mm Hg increase). The CO diet stimulated a greater increase in heart rate than the LD diet (p<0. 05; 32. 8 ± 7. 8 vs. 14. 1 ± 5. 8 bpm increase). Ganglionic blockade with chlorisondamine caused an increase in HR in both lean groups and in the obese CO group, but not the obese LD group, consistent with a decrease in parasympathetic tone to the heart in the dogs overfed saturated fat. Obesity enhanced the heart rate response to β‐badrenergic stimulation by isoproterenol in the LD, but not CO group. The LD diet increased circulating insulin and decreased insulin sensitivity, whereas the CO diet had no effect on either parameter. These findings suggest that the composition of dietary fat can modulate the autonomic and metabolic adaptations induced by dietary obesity.