Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma:: a study of 128 cases of non-invasive neoplasms
Aurora-A/STK-15 is a predictive factor for recurrent behaviour in non-invasive bladder carcinoma:: a study of 128 cases of non-invasive neoplasms
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DOI：
10.1007/s00428-007-0383-x
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发表时间：
2007-04-01
期刊：
影响因子：
3.5
通讯作者：
Paradis, V.
中科院分区：
文献类型：
--
作者：
Comperat, E.;Camparo, P.;Paradis, V.
Aurora-A是丝氨酸/苏氨酸激酶的一个成员，参与有丝分裂和中心体成熟。在一些恶性肿瘤中，尤其是膀胱癌中，已经发现极光a水平升高。目前还没有免疫组织化学标志物能够预测浅表性膀胱癌患者的临床预后，除了MIB-1可以作为复发和进展的预测标志物。目的是研究不同侵袭程度的pTa乳头状尿路上皮肿瘤（低恶性潜能[PUNLMP]、非侵袭性乳头状尿路上皮癌低分级[NILGC]、非侵袭性乳头状尿路上皮癌高分级[NIHGC]和原位癌）的浅表性膀胱癌组织微阵列中aurura - a和mb -1的表达情况。我们分析了这两种标志物对肿瘤复发的预测价值、特异性和敏感性。Aurora-A是预测肿瘤复发的敏感标志物，尤其是pTa (PUNLMP， NILGC; PUNLMP p < 0.001, NILGC p < 0.001)，免疫组化染色与临床预后的相关性有统计学意义。PUNLMP组和NILGC组的mb -1表达差异有统计学意义p=0.002和p=0.03。在预测pTa膀胱肿瘤复发方面，Aurora-A比mb -1更敏感。两种指标的结合似乎对复发有很强的预测价值（p < 0.001）。
Aurora-A, a member of serine/threonine kinase, is implied in mitosis and centrosome maturation. Increasing levels of Aurora-A have been shown to be present in several malignancies and especially in bladder cancer. No immunohistochemical marker has shown to be able to predict the clinical outcome of patients with superficial bladder cancer, except MIB-1, as a predictive marker of relapse and progression. The aim was to investigate the expression of Aurora-A and MIB-1 in tissue micro arrays of superficial bladder cancer representative of pTa papillary urothelial neoplasm with different degrees of aggressiveness (low malignant potential [PUNLMP], non-invasive papillary urothelial carcinoma low grade [NILGC], non-invasive papillary urothelial carcinoma high grade [NIHGC] and carcinoma in situ). We analysed predictive values of both markers, their specificity and sensitivity in tumor recurrence. Aurora-A was a sensitive marker to predict tumor recurrence especially for pTa (PUNLMP, NILGC; PUNLMP p < 0.001, NILGC p < 0.001) with statistical significant correlation between immunohistochemical staining and clinical outcome. MIB-1 expression displayed statistical difference p=0.002 in the PUNLMP group and p=0.03 in the NILGC group. Aurora-A is a more sensitive marker than MIB-1 to predict relapse in pTa bladder neoplasias. The combination of both markers seems to have a very powerful predictive value of recurrence (p < 0.001).