The effect of local simvastatin delivery strategies on mandibular bone formation in vivo
The effect of local simvastatin delivery strategies on mandibular bone formation in vivo
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DOI：
10.1016/j.biomaterials.2007.12.045
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发表时间：
2008-04-01
期刊：
影响因子：
14
通讯作者：
Reinhardt, Richard A.
中科院分区：
文献类型：
--
作者：
Lee, Yeonju;Schmid, Marian J.;Reinhardt, Richard A.
已知全身性辛伐他汀可降低胆固醇并刺激适度的骨形成，但在聚乳酸圆顶中的局部手术放置可导致稳健的骨形成和局部肿胀。研究了一种侵入性较小且更灵活的注射方案，以评价与手术植入相比的骨诱导作用。评价骨形成率、短期和长期骨增量组织学和机械性能，以表征大鼠双侧下颌骨模型（同一动物的试验侧和对照侧）中的新骨。结果表明，与辛伐他汀圆顶植入（24天时增加43%）相比，多次注射0.5 mg辛伐他汀可有效降低软组织肿胀，同时保持骨生长（24天时骨宽度增加60%）。与对照组相比，辛伐他汀侧的骨形成率显著较高，尤其是在圆顶。三点弯曲测试显示，注射辛伐他汀后24天的最大断裂力和刚度更高。长期评价显示，注射后24天形成的最大新骨的55%保留在90天时。(C)2008爱思唯尔有限公司保留所有权利。
Systemic simvastatin is known to reduce cholesterol and stimulate modest bone formation, but local surgical placement in polylactic acid domes causes robust bone formation and local swelling. A less invasive and more flexible injection protocol was studied to evaluate the bone-inducing effects compared to surgical implantation. Bone formation rate, short- and long-term bone augmentation histology, and mechanical properties were evaluated to characterize the new bone in a rat bilateral mandible model (test and control sides in same animal). Results demonstrated that multiple (3) injections of 0.5 mg simvastatin effectively reduced soft tissue swelling while preserving bone growth (60% increase of bone width at 24 days) compared to simvastatin dome placement (43% increase at 24 days). Compared to controls, bone formation rate was significantly higher on the simvastatin side, especially in the dome. Three-point bending tests revealed higher maximum force to fracture and stiffness at 24 days with simvastatin injections. Long-term evaluation showed that 55% of maximum new bone formed 24 days post-injection was retained at 90 days. (C) 2008 Elsevier Ltd. All rights reserved.