Imaging Mass Spectrometry Using a Delay-Line Detector
Imaging Mass Spectrometry Using a Delay-Line Detector
复制标题
使用延迟线检测器进行成像质谱分析
DOI：
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发表时间：
2010
影响因子：
1.3
通讯作者：
R. Heeren
中科院分区：
文献类型：
--
作者：
Martin Froesch;S. Luxembourg;Duncan Verheijde;R. Heeren
Microscope mode mass spectrometric imaging is crucially dependent on the availability of a high-resolution, position-resolved time-of-flight detector. Here, a new detection method for microscope mode imaging mass spectrometry is presented. A delay-line detector has been used for the first time as a position-sensitive detector in imaging mass spectrometry. The method is implemented on a matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF), as well as a secondary ion mass spectrometry time-of-flight (SIMS-ToF) instrument. Trypsinogen and bovine serum albumin samples have been used with a metal mask to determine the spatial resolution of the new detector using the MALDI-ToF instrument. The new detector set-up was successfully employed to generate mass resolved SIMS images from biological structures on the surface of thin tissue sections. The biological samples studied were taken from tumor grown from xenografted breast cancer cell lines and chicken embryonal sections.
影响因子：
10.5
作者：
Kumar, A;Agarwal, S;Snyder, M
通讯作者：
Snyder, M
影响因子：
7.4
作者：
Khatib-Shahidi, Sheerin;Andersson, Malin;Caprioli, Richard M.
通讯作者：
Caprioli, Richard M.