IRON OVERLOAD IN HEMODIALYSIS-PATIENTS INCREASES THE RISK OF BACTEREMIA - A PROSPECTIVE-STUDY
IRON OVERLOAD IN HEMODIALYSIS-PATIENTS INCREASES THE RISK OF BACTEREMIA - A PROSPECTIVE-STUDY
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DOI：
10.1093/ndt/5.2.130
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发表时间：
1990-02-01
影响因子：
6.1
通讯作者：
VANLANDUYT, HW
中科院分区：
文献类型：
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作者：
BOELAERT, JR;DANEELS, RF;VANLANDUYT, HW
对来自一个血液透析单位的患者进行了为期2年的前瞻性研究，研究了与输血铁超载程度相关的菌血症发生率，对158名患者进行了181.3患者年的总随访。每3个月，根据血清铁蛋白将患者分为三组之一：< 500、500-1000或> 1000 μ g/l。在181.3患者年（年发病率为0.160）内记录了29例菌血症。对于铁蛋白< 500和500-1000 μ g/l，菌血症的年发病率为0.1173和0.1101（无显著差异），两组的累积发病率为0.1164。在铁蛋白> 1000 μ g/l组中，发病率为0.3404（P ≤ 0.001）。0.005相对于铁蛋白≤1000 μ g/l组）。根据患者入组研究时的年龄和血液透析治疗的持续时间进行分层后，铁蛋白> 1000组的菌血症发生率高于≥ 1000组。1000 μ g/l组持续存在（P ≤ 0.05）。 0.005）。这项前瞻性研究证实了先前的回顾性研究，即血液透析中获得性输血铁超负荷与菌血症风险增加相关。
The incidence of bacteraemia in relation to the degree of transfusional iron overload was studied prospectivey in patients from one haemodialysis unit over a 2-year period, with a total follow-up of 181.3 patient-years in 158 patients. Every 3 months, the patients were classified according to the serum ferritin in one of three groups: < 500, 500-1000 or > 1000 .mu.g/l. Twenty-nine episodes of bacteraemia were recorded over 181.3 patient-years (yearly incidence of 0.160). The yearly incidence of bacteraemia was 0.1173 and 0.1101 for ferritin < 500 and 500-1000 .mu.g/l (no significant difference), with a cumulative incidence for both groups of 0.1164. In the ferritin > 1000 .mu.g/l group, the incidence was 0.3404 (P .ltoreq. 0.005 versus the ferritin .ltoreq. 1000 .mu.g/l group). After stratification for patient''s age at inclusion in the study) and duration of haemodialysis therapy, the higher incidence of bacteraemia in the ferritin > 1000 versus .gtoreq. 1000 .mu.g/l groups persisted (P .ltoreq. 0.005). This prospective study confirms previous retrospective studies in showing that acquired transfusional iron overload in haemodialysis is associated with a greater risk of bacteraemia.