Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation.
Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation.
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DOI：
10.4049/jimmunol.0903180
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发表时间：
2010-01-15
期刊：
影响因子：
--
通讯作者：
Cursiefen C
中科院分区：
文献类型：
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作者：
Dietrich T;Bock F;Yuen D;Hos D;Bachmann BO;Zahn G;Wiegand S;Chen L;Cursiefen C
本研究的目的是确定血管（血管生成）与淋巴管（淋巴管生成）在移植后介导免疫反应的相对重要性。使用小鼠角膜移植模型，比较了不同预血管化和无血管化受体床中的移植物存活率。将供体角膜（C57 BL/6）移植到未发炎或发炎的无血管、仅预血运化或预血运化和预淋巴血管化的受体小鼠眼（BALB/C）中。使用抗血管内皮生长因子受体3抗体和抗整合素α5小分子实现了对淋巴管生成的选择性抑制。与移植到完全无血管的正常受者相比，仅将移植物放置在预先血运化的受者床中具有相似的良好移植物存活，而预先存在淋巴管显著恶化了角膜移植物存活（p < 0.05）。淋巴管似乎对角膜移植后的排斥反应有重要作用。这可能允许进行选择性的、临时的围手术期抗淋巴管生成治疗，以促进移植物存活而不影响血管，即使在实体器官移植后也是如此。
The purpose of this study was to determine the relative importance of blood vessels (hemangiogenesis) versus lymphatic vessels (lymphangiogenesis) in mediating immunological responses after transplantation. Using the murine model of corneal transplantation, graft survival was compared in differentially prevascularized and avascular recipient beds. Donor corneas (C57BL/6) were transplanted into uninflamed or inflamed avascular, prehemvascularized only or prehemvascularized and prelymphvascularized recipient murine eyes (BALB/C). Selective inhibition of lymphangiogenesis was achieved using antivascular endothelial growth factor receptor 3 Abs and anti-integrin α5 small molecules. Grafts placed into only prehemvascularized recipient beds had a similarly good graft survival compared with grafts placed into completely avascular, normal recipients, whereas the pre-existence of lymphatic vessels significantly deteriorated corneal graft survival (p < 0.05). Lymphatic vessels seem to contribute significantly to graft rejection after (corneal) transplantation. That may allow for selective, temporary, perioperative antilymphangiogenic treatment to promote graft survival without affecting blood vessels, even after solid organ transplantation.