Accelerated T2 mapping combining parallel MRI and model-based reconstruction: GRAPPATINI
Accelerated T2 mapping combining parallel MRI and model-based reconstruction: GRAPPATINI
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DOI：
10.1002/jmri.25972
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发表时间：
2018-08-01
影响因子：
4.4
通讯作者：
Krueger, Gunnar
中科院分区：
文献类型：
--
作者：
Hilbert, Tom;Sumpf, Tilman J.;Krueger, Gunnar
背景定量 T-2 测量对细胞内和细胞外的水分积聚以及髓鞘脱落非常敏感。因此，T-2 定量有望成为疾病的良好生物标志物。目的 加快 T-2 定量和随后生成合成 T-2 加权（T-2-w）图像对比度的速度，以用于临床研究和常规治疗。为此，通过并行成像（GRAPPA）扩展了最近开发的基于模型的快速T-2和M-0量化方法（MARTINI），该方法基于欠采样k空间，可在不到2分钟的采集时间内获得整个大脑的T-2-w图像，从而实现高分辨率T-2映射。研究类型前瞻性横断面研究.受试者/模型14名健康受试者和一个多功能模型.场强/序列3T扫描仪上的Carr-Purcell-Meiboom-Gill序列.评估对加速T-2量化的准确性和可重复性进行了评估。验证包括对模型以及健康志愿者的大脑、膝关节、前列腺和肝脏进行核磁共振成像研究。根据计算的 T-2 和 M-0 地图生成合成 T-2-w 图像，并与传统的快速自旋回波（SE）图像进行比较。结果MARTINI 和 GRAPPA（GRAPPATINI）的组合使 T-2 映像绘制方案的速度加快了 10 倍，采集时间仅为 1:44 分钟，且全脑覆盖。与 10 倍 MARTINI 重建（37.6%）相比，GRAPPATINI 的 RMSD 增加较少（4.3%）。再现性测试表明，扫描和重新扫描之间相关区域 T-2 值的标准偏差（SD）较低 (
BackgroundQuantitative T-2 measurements are sensitive to intra- and extracellular water accumulation and myelin loss. Therefore, quantitative T-2 promises to be a good biomarker of disease. However, T-2 measurements require long acquisition times.PurposeTo accelerate T-2 quantification and subsequent generation of synthetic T-2-weighted (T-2-w) image contrast for clinical research and routine. To that end, a recently developed model-based approach for rapid T-2 and M-0 quantification (MARTINI) based on undersampling k-space, was extended by parallel imaging (GRAPPA) to enable high-resolution T-2 mapping with access to T-2-w images in less than 2 minutes acquisition time for the entire brain.Study TypeProspective cross-sectional study.Subjects/PhantomFourteen healthy subjects and a multipurpose phantom.Field Strength/SequenceCarr-Purcell-Meiboom-Gill sequence at a 3T scanner.AssessmentThe accuracy and reproducibility of the accelerated T-2 quantification was assessed. Validations comprised MRI studies on a phantom as well as the brain, knee, prostate, and liver from healthy volunteers. Synthetic T-2-w images were generated from computed T-2 and M-0 maps and compared to conventional fast spin-echo (SE) images.Statistical TestsRoot mean square distance (RMSD) to the reference method and region of interest analysis.ResultsThe combination of MARTINI and GRAPPA (GRAPPATINI) lead to a 10-fold accelerated T-2 mapping protocol with 1:44 minutes acquisition time and full brain coverage. The RMSD of GRAPPATINI increases less (4.3%) than a 10-fold MARTINI reconstruction (37.6%) in comparison to the reference. Reproducibility tests showed low standard deviation (SD) of T-2 values in regions of interest between scan and rescan (