Lobozoanthamine, a new zoanthamine-type alkaloid from the Indonesian soft coral Lobophytum sp.

Lobozoanthamine, a new zoanthamine-type alkaloid from the Indonesian soft coral Lobophytum sp.
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DOI:
10.1016/j.tetlet.2008.02.028
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发表时间:
2008-03-31
影响因子:
1.8
通讯作者:
Cerrano, Carlo
Cerrano, Carlo
中科院分区:
化学4区
文献类型:
--
作者:
Fattorusso, Ernesto;Romano, Adriana;Cerrano, Carlo

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从印度尼西亚软珊瑚Lobophytum sp.中分离到一个新的Zoanthamine型生物碱家族成员--Lobozoanthamine(1),这是首次从海洋无脊椎动物中分离到Zoanthamine型生物碱。通过对2D NMR数据的解释和应用改进的Mosher方法,建立了Lobozoanthamine(1)的密集官能化七环立体结构。(C)2008爱思唯尔有限公司保留所有权利。
A new member of the family of zoanthamine-type alkaloids, lobozoanthamine (1), has been isolated from the Indonesian soft coral Lobophytum sp. This represents the first report of a zoanthamine-type alkaloid from a marine invertebrate different from zoanthids. The densely functionalized heptacyclic stereostructure of lobozoanthamine (1) has been established through the interpretation of 2D NMR data and application of the modified Mosher method. (C) 2008 Elsevier Ltd. All rights reserved.