The Regulatory Network of METTL3 in the Nervous System: Diagnostic Biomarkers and Therapeutic Targets.
The Regulatory Network of METTL3 in the Nervous System: Diagnostic Biomarkers and Therapeutic Targets.
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DOI：
10.3390/biom13040664
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发表时间：
2023-04-11
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
甲基转移酶样3（Methyltransferase-like 3，简称肌L3）是N6-甲基腺苷受体的一个典型组分，具有甲基转移酶活性，并在RNA上沉积甲基。目前，越来越多的研究表明胃L3参与了神经生理和病理事件的调节。但目前尚无综述全面总结和分析胃L3在这些事件中的作用和机制。在此，我们重点综述了L3在调节正常神经生理（神经发生、突触可塑性和胶质可塑性、神经发育、学习和记忆）和神经病理（自闭症谱系障碍、重度抑郁症、神经退行性疾病、脑肿瘤、脑损伤和其他脑疾病）事件中的作用。我们的综述发现，尽管胃L3的下调水平在神经系统中通过不同的作用和机制发挥作用，但它主要使神经生理事件失活，并触发或阻止神经病理事件。此外，我们的综述表明，胃L3可用作神经系统的诊断生物标志物和治疗靶点。总之，我们的综述提供了一个最新的研究概述胃L3在神经系统。此外，已经绘制了神经系统中胃L3的调控网络，这可以为未来的研究提供方向，为临床诊断提供生物标志物，并为疾病治疗提供靶点。此外，这篇综述提供了一个全面的观点，这将有助于我们更好地了解胃L3在神经系统中的功能。
Methyltransferase-like 3 (METTL3) is a typical component of N6-methyladenosine writers that exhibits methyltransferase activity and deposits methyl groups on RNA. Currently, accumulating studies have demonstrated the involvement of METTL3 in the regulation of neuro-physiological and pathological events. However, no reviews have comprehensively summarized and analyzed the roles and mechanisms of METTL3 in these events. Herein, we are focused on reviewing the roles of METTL3 in regulating normal neurophysiological (Neurogenesis, Synaptic Plasticity and Glial Plasticity, Neurodevelopment, Learning and Memory,) and neuropathological (Autism Spectrum Disorder, Major Depressive Disorder, Neurodegenerative disorders, Brain Tumors, Brain Injuries, and Other Brain Disorders) events. Our review found that although the down-regulated levels of METTL3 function through different roles and mechanisms in the nervous system, it primarily inactivates neuro-physiological events and triggers or worsens neuropathological events. In addition, our review suggests that METTL3 could be used as a diagnostic biomarker and therapeutic target in the nervous system. Collectively, our review has provided an up-to-date research outline of METTL3 in the nervous system. In addition, the regulatory network for METTL3 in the nervous system has been mapped, which could provide directions for future research, biomarkers for clinical diagnosis, and targets for disease treatment. Furthermore, this review has provided a comprehensive view, which could improve our understanding of METTL3 functions in the nervous system.
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