The effect of transcranial direct current stimulation on the cortical activation by motor task in the human brain: An fMRI study
The effect of transcranial direct current stimulation on the cortical activation by motor task in the human brain: An fMRI study
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DOI：
10.1016/j.neulet.2009.05.037
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发表时间：
2009-08-28
影响因子：
2.5
通讯作者：
Kwon, Yong Hyun
中科院分区：
文献类型：
--
作者：
Jang, Sung Ho;Ahn, Sang Ho;Kwon, Yong Hyun
目的：利用功能磁共振成像(FMRI)技术，研究经颅直流电刺激(Tdcs)对人脑手部初级运动皮质的激活作用是否会改变手部运动引起的皮质激活。方法：选择14名健康受试者，随机分为tdcs组和假手术组，每组7例。分别于干预前和干预20min后(tDCs组：正极tDCSs，假刺激组：假刺激)进行fMRI检查，动作频率为1 Hz。结果：tDCs组大鼠初级感觉运动皮质(SM1)中tDCs的激活明显增强(p<；0.05)。相比之下，假手术组的SM1在体素计数和强度方面明显减少(p<；0.05)。没有受试者抱怨有任何不良症状或体征。结论：阳极型TDCs可增强人脑运动皮质的兴奋性。提示tDCs是一种有效的脑功能调节方式。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: We attempted to evaluate whether cortical activation resulting from hand movements is changed by transcranial direct current stimulation (tDCS) applied on the primary motor cortex for the hand in the human brain, using functional MRI (fMRI). Methods: Fourteen normal subjects were recruited; subjects were randomly assigned to either the tDCS group (n = 7) or the sham group (n = 7). fMRI was performed with hand grasp-release movements at 1 Hz before and after 20 min of intervention (the tDCS group: anodal tDCS, the sham group: sham stimulation). Results: The activation of the tDCS underlying primary sensorimotor cortex (SM1) was significantly increased in the tDCS group (p < 0.05). By contrast, the SM1 was significantly decreased in the sham group in terms of the voxel count and intensity (p < 0.05). No subjects complained of any adverse symptoms or signs. Conclusion: We demonstrated that anodal tDCS increased the cortical excitability of the underlying motor cortex in the human brain. It seems that tDCS is an effective modality to modulate brain function. (C) 2009 Elsevier Ireland Ltd. All rights reserved.