Endothelin type A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure
Endothelin type A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure
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DOI：
10.1161/01.hyp.37.2.485
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发表时间：
2001-02-01
期刊：
影响因子：
8.3
通讯作者：
Granger, JP
中科院分区：
文献类型：
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作者：
Alexander, BT;Rinewalt, AN;Granger, JP
妊娠大鼠子宫灌注压的慢性降低与平均动脉压（MAP）的显著升高和肾功能的降低有关。本研究的目的是研究内皮素在慢性妊娠大鼠子宫灌注压慢性降低时介导高血压的作用。子宫灌注压慢性降低（123.0+/-1.8 mm HE）的妊娠大鼠MAP明显高于对照组（101.3+/-4.0 mm Hg）。通过核糖核酸酶保护实验检测，内皮素前原mRNA在肾髓质的表达也显著升高(>45%,P22%， P
A chronic reduction in uterine perfusion pressure in pregnant rats is associated with a significant elevation in mean arterial pressure (MAP) and reduction in kidney function. The purpose of this study was to examine the role of endothelin in mediating the hypertension in response to chronic reductions in uterine perfusion pressure in conscious, chronically instrumented, pregnant rats. MAP in pregnant rats with chronic reductions in uterine perfusion pressure (123.0+/-1.8 mm HE) was significantly higher than that in control pregnant rats (101.3+/-4.0 mm Hg). Renal expression of preproendothelin mRNA as determined by ribonuclease protection assay was also significantly elevated in the medulla (>45%, P22%, P