Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest.
Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest.
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DOI：
10.1249/00005768-199305001-01008
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发表时间：
1993-05
影响因子：
3.3
通讯作者：
J. Romijn;S. Klein;E. Coyle;L. Sidossis;R. Wolfe
中科院分区：
文献类型：
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作者：
J. Romijn;S. Klein;E. Coyle;L. Sidossis;R. Wolfe
基础全身脂质动力学进行了评估，在9个耐力训练的自行车手和10个未经训练的健康对照。通过输注[2 H5]甘油和[2 H2]棕榈酸酯并结合间接量热法测定甘油的出现率（Ra）（全身脂解的指数）、棕榈酸酯的Ra（脂肪酸释放的指数）和甘油三酯-脂肪酸循环率（脂解过程中释放的脂肪酸的再酯化）。所有受试者均在禁食过夜后休息时进行研究。运动员的甘油Ra和游离脂肪酸Ra（分别为7.33 +/- 0.68和14.88 +/- 1.35 mumol.kg-1 x min-1）比未经训练的对照组（分别为2.53 +/- 0.15和7.64 +/- 0.92 mumol.kg-1 x min-1; P < 0.02）高2 - 3倍。运动员的总甘油三酯-脂肪酸循环速率（16.86 +/- 2.07 mumol.kg-1 x min-1）大约是对照组（3.91 +/- 0.36 mumol.kg-1 x min-1）的四倍。两组的胰岛素和儿茶酚胺（调节全身脂质动力学的激素）的血浆浓度相同。我们的结论是，静息基础脂质动力学显着增加参与剧烈耐力训练的运动员，这增强了运动开始时迅速增加脂肪酸氧化的潜力。
Basal whole body lipid kinetics were evaluated in nine endurance-trained cyclists and 10 untrained healthy controls. The rate of appearance (Ra) of glycerol (an index of whole body lipolysis), the Ra of palmitate (an index of fatty acid release), and the rate of triglyceride-fatty acid cycling (reesterification of fatty acids released during lipolysis) were determined by infusing [2H5]glycerol and [2H2]palmitate in conjunction with indirect calorimetry. All subjects were studied while they were at rest after fasting overnight. Glycerol Ra and free fatty acid Ra in the athletes (7.33 +/- 0.68 and 14.88 +/- 1.35 mumol.kg-1 x min-1, respectively) were two- to threefold higher than the values in untrained control subjects (2.53 +/- 0.15 and 7.64 +/- 0.92 mumol.kg-1 x min-1, respectively; P < 0.02). The total rate of triglyceride-fatty acid cycling was approximately four-fold higher in the athletes (16.86 +/- 2.07 mumol.kg-1 x min-1) than in the control subjects (3.91 +/- 0.36 mumol.kg-1 x min-1). Plasma concentrations of insulin and catecholamines, hormones that regulate whole body lipid kinetics, were the same in both groups. We conclude that resting basal lipid kinetics are markedly increased in athletes involved in strenuous endurance training and that this enhances the potential for increasing fatty acid oxidation rapidly at the onset of exercise.