BIOSYNTHESIS OF MODIFIED NUCLEOSIDE-Q IN TRANSFER-RNA

BIOSYNTHESIS OF MODIFIED NUCLEOSIDE-Q IN TRANSFER-RNA
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DOI:
10.1093/nar/3.2.393
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发表时间:
1976-01-01
影响因子:
14.9
通讯作者:
NISHIMURA, S
NISHIMURA, S
中科院分区:
生物学2区
文献类型:
--
作者:
KUCHINO, Y;KASAI, H;NISHIMURA, S

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在tRNA中修饰的核苷Q,7-(4,5-dihydroxyl-lcyclopenten-3-yl-aminomethyl)-7-deazaguanosine,的生物合成过程中,前体分子鸟嘌呤中第8位的碳原子与氮原子N-7一起被排出,其方式类似于核苷类抗生素托育霉素的生物合成。
During biosynthesis of the modified nucleoside Q, 7-(4,5-dihydroxyl-lcyclopenten-3-yl-aminomethyl)-7-deazaguanosine, in tRNA, the carbon atom at position 8 in precursor molecule guanine was expelled together with the nitrogen atom N-7 in a fashion similar to that in the biosynthesis of the nucleoside antibiotic toyocamycin.