Inside Back Cover: Model‐Based Nanoengineered Pharmacokinetics of Iron‐Doped Copper Oxide for Nanomedical Applications (Angew. Chem. Int. Ed. 5/2020)
Inside Back Cover: Model‐Based Nanoengineered Pharmacokinetics of Iron‐Doped Copper Oxide for Nanomedical Applications (Angew. Chem. Int. Ed. 5/2020)
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封底内页：用于纳米医学应用的铁掺杂氧化铜的基于模型的纳米工程药代动力学（Angew Chem Int Ed 5/2020）
DOI：
10.1002/anie.201916183
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发表时间：
2020
影响因子：
--
通讯作者：
Soenen
中科院分区：
文献类型：
--
作者：
Manshian;Rios Luci;Tsikourkitoudi;Deligiannakis;Birkenstock;Pokhrel;Mädler;Soenen
.铁掺杂氧化铜纳米粒子的受控溶解动力学在靶向纳米医学中的应用。在他们的研究文章1828页，L。Mädler，SJ Soenen等人提出了一种基于模型的方法，用于调节铜的溶解动力学和细胞内释放，为癌症治疗打开了一个治疗窗口。铜稳态调节外周细胞中缓慢释放的升高的铜水平，但不足以在癌细胞中快速释放。
. The controlled dissolution kinetics…… of iron-doped copper oxide nanoparticles are applied in targeted nanomedicine. In their Research Article on page 1828, L. Mädler, SJ Soenen et al. present a model-based approach for adjusting the dissolution kinetics and intracellular release of copper that opens a therapeutic window for cancer treatment. Copper homeostasis regulates elevated copper levels for the slow release in peripheral cells but is insufficient for the fast release in cancer cells.