Prevalence and short-term outcome of acute kidney injury in patients with acute-on-chronic liver failure: A meta-analysis
Prevalence and short-term outcome of acute kidney injury in patients with acute-on-chronic liver failure: A meta-analysis
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DOI：
10.1111/jvh.13287
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发表时间：
2020-03-18
影响因子：
2.5
通讯作者：
Xun, Yunhao
中科院分区：
文献类型：
--
作者：
Jiang, Weiyun;Hu, Yechao;Xun, Yunhao
急性慢性肝功能衰竭（ACLF）患者的急性肾损伤（AKI）是与肝硬化患者不同的综合征，但其特征较少。本荟萃分析的目的是研究AKI对ACLF预后的影响。我们检索了PubMed、Web of Science和Cochrane Library，检索了2011年至2019年评估AKI对ACLF结果影响的原创文章。计算1个月和3个月死亡率的优势比（OR）和95%可信区间（CI）。评价血管收缩剂治疗肝肾综合征(HRS)-AKI的有效率。纳入8篇相关文章，共3610例患者。ACLF患者AKI患病率为41% （95% CI 32%-50%）。AKI的存在与ACLF的1个月死亡率（OR 3.98, 95% CI 3.09-5.12; P < 0.001）和3个月死亡率（OR 4.98, 95% CI 3.59-6.92; P < 0.001）显著相关。此外，>= 2期AKI患者的3个月死亡率高于1期（OR 3.89, 95% CI 2.60-5.82; P < .001）， 3期患者的死亡率高于1期
Acute kidney injury (AKI) in patients with acute-on-chronic liver failure (ACLF) is a distinct syndrome to that in patients with cirrhosis, yet is less characterized. The aim of this meta-analysis was to investigate the impact of AKI on outcome of ACLF. We searched PubMed, Web of Science and Cochrane Library for original articles that evaluated the impact of AKI on outcome of ACLF from 2011 to 2019. Odds ratio (OR) with 95% confidence interval (CI) for 1-month and 3-month mortality was calculated. The response rate of vasoconstrictor for hepatorenal syndrome (HRS)-AKI was assessed. Eight relevant articles with 3610 patients were included. The prevalence of AKI in ACLF patients was 41% (95% CI 32%-50%). The presence of AKI was significantly associated with 1-month mortality of ACLF (OR 3.98, 95% CI 3.09-5.12; P < .001) and 3-month mortality (OR 4.98, 95% CI 3.59-6.92; P < .001). Additionally, patients with AKI stage >= 2 showed a higher 3-month mortality than stage 1 (OR 3.89, 95% CI 2.60-5.82; P < .001), and those of stage 3 had a higher mortality than stage