Metabolic products of microorganisms 133. Inhibition of ribosomal peptidyl transferase by hikizimycin, a nucleoside antibiotic.
Metabolic products of microorganisms 133. Inhibition of ribosomal peptidyl transferase by hikizimycin, a nucleoside antibiotic.
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微生物的代谢产物 133. 核苷抗生素 hikizimycin 对核糖体肽基转移酶的抑制。
DOI：
10.7164/antibiotics.27.783
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Kenji Uchida;H.
核苷类抗生素hikizimycin抑制紫丁香假单胞菌完整细胞中的蛋白质生物合成和大肠杆菌无细胞系统中聚u导向的聚苯丙氨酸生物合成。抗生素不影响苯丙氨酸向tRNA的转移，也不影响苯丙酰tRNA与核糖体-聚U复合物的附着。Hikizimycin在嘌呤霉素反应中起明显的抑制剂作用。
The nucleoside antibiotic hikizimycin was found to inhibit protein biosynthesis in intact cells of Pseudomonas syringiae and the poly U-directed polyphenylalanine biosynthesis in a cell-free system of E. coli. The antibiotic did not affect the transfer of phenylalanine to tRNA or the attachment of phenylalanyl-tRNA to the ribosome-poly U complex. Hikizimycin acts as a marked inhibitor in the puromycin reaction.