MicroRNAs and cell cycle regulation
MicroRNAs and cell cycle regulation
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DOI：
10.4161/cc.6.17.4641
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发表时间：
2007-09-01
期刊：
影响因子：
4.3
通讯作者：
Linsley, Peter S.
中科院分区：
文献类型：
--
作者：
Carleton, Michael;Cleary, Michele A.;Linsley, Peter S.
MicroRNA (microRNA) 含量丰富，类似于 21-25 核苷酸 (nt) 非编码 RNA，可介导 mRNA 靶标的序列特异性、转录后抑制。新出现的证据表明，几种 microRNA 的靶标转录物编码直接或间接参与细胞周期进程和细胞增殖的蛋白质。此外，microRNA水平的改变可能导致病理状况，包括与细胞周期控制丧失相关的肿瘤发生。在这篇综述中，我们重点介绍了将 microRNA 与哺乳动物细胞周期调控联系起来的最新数据。我们描述了特定 miRNA 如何在控制细胞周期检查点的途径中发挥作用。我们讨论了支持某些 microRNA 活性可能依赖于细胞周期这一观点的新证据，并概述了 microRNA 靶点的协调调控如何影响细胞周期进程。
MicroRNAs (microRNAs) are abundant, similar to 21-25 nucleotide (nt) non-coding RNAs that mediate sequence-specific, post-transcriptional repression of mRNA targets. Emerging evidence suggests that several microRNAs target transcripts that encode proteins directly or indirectly invovled in cell cycle progression and cellular proliferation. Moreover, alteration of microRNA levels can contribute to pathological conditions, including tumorigenesis, that are associated with loss of cell cycle control. In this review we highlight recent data linking microRNAs to mammalian cell cycle regulation. We describe how specific miRNAs function within pathways that control cell cycle checkpoints. We discuss emerging evidence that support the idea that some microRNA activity may be cell cycle dependent, and we outline how the coordinate regulation of microRNA targets may influence cell cycle progression.