Thrombus Obliteration by Rapid Percutaneous Endovenous Intervention in Deep Venous Occlusion (TORPEDO) Trial: Midterm Results
Thrombus Obliteration by Rapid Percutaneous Endovenous Intervention in Deep Venous Occlusion (TORPEDO) Trial: Midterm Results
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DOI：
10.1583/11-3674mr.1
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发表时间：
2012-04-01
影响因子：
2.6
通讯作者：
Sharifi, Jalaladdin
中科院分区：
文献类型：
--
作者：
Sharifi, Mohsen;Bay, Curt;Sharifi, Jalaladdin
目的：介绍一项随机研究的中期结果，该研究比较了经皮静脉内介入（PEI）+抗凝与单独抗凝在减少急性症状性近端深静脉血栓形成（DVT）中静脉血栓栓塞（VTE）和血栓后综合征（PTS）方面的安全性和有效性。方法：TORPEDO试验是一项随机化研究，旨在证明6个月时PEVI在减少VTE和PTS方面的优效性;在该试验中，183名患者（103名男性;平均年龄61 ± 11岁）患有症状性近端DVT的患者被随机分配接受PEI+抗凝治疗（n=91）或单独抗凝治疗（n=92）。结果：在6个月时，复发性静脉血栓栓塞发生率，PEVI+抗凝组为2.3%，单纯抗凝组为14.8%（p=0.003）; PTS发生率，PEVI +抗凝组为3.4%，单纯抗凝组为27.2%（p=0.003）。
Purpose: To present midterm results from a randomized study comparing the safety and efficacy of percutaneous endovenous intervention (PEVI) + anticoagulation vs. anticoagulation alone in the reduction of venous thromboembolism (VTE) and post-thrombotic syndrome (PTS) in acute symptomatic proximal deep venous thrombosis (DVT).Methods: The TORPEDO trial was a randomized study to demonstrate superiority of PEVI in the reduction of the VTE and PTS at 6 months; in that trial, 183 patients (103 men; mean age 61 +/- 11 years) with symptomatic proximal DVT were randomized to receive PEVI + anticoagulation (n=91) or anticoagulation alone (n=92). PEVI consisted of one or more of a combination of thrombectomy, balloon venoplasty, stenting, and/or local low-dose thrombolytic therapy.Results: At 6 months, recurrent VTE developed in 2.3% of the PEVI + anticoagulation group vs. 14.8% in the anticoagulation only group (p=0.003); PTS developed in 3.4% vs. 27.2% (p