Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer.
Small extracellular vesicles: from promoting pre-metastatic niche formation to therapeutic strategies in breast cancer.
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DOI：
10.1186/s12964-022-00945-w
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发表时间：
2022-09-12
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--
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乳腺癌是女性最常见的癌症，到目前为止，乳腺癌转移的死亡率不容忽视。乳腺癌的转移是一个复杂的、阶段性的过程，转移扩散的模式不是随机的。转移前的生态位作为特定器官转移的场所，是肿瘤细胞定植的有利环境。随着检测技术的进步，转移前生态位在乳腺癌转移中的作用正在被发现。SEV(细胞外小泡)可以运送货物，这对转移前壁龛的形成至关重要。SEV参与创造促进肿瘤侵袭的远程微环境的多个方面，包括炎症分子的分泌、免疫抑制、血管生成和血管通透性的增强，以及对间质环境的调节。在这里，我们讨论乳腺癌来源的SEV有助于转移前利基的多方面机制。此外，还讨论了SEV作为生物标志物和抗转移治疗，特别是它们在运输外体microRNAs方面的应用。SEV的研究可能为乳腺癌的免疫治疗和靶向治疗提供洞察力，我们也提供了它们在抗肿瘤转移中的潜在作用的概述。视频摘要在线版本包含可在10.1186/s12964-022-00945-w上查阅的补充材料。
Breast cancer is the most common cancer in females, and to date, the mortality rate of breast cancer metastasis cannot be ignored. The metastasis of breast cancer is a complex, staged process, and the pattern of metastatic spread is not random. The pre-metastatic niche, as an organ-specific home for metastasis, is a favourable environment for tumour cell colonization. As detection techniques improve, the role of the pre-metastatic niche in breast cancer metastasis is being uncovered. sEVs (small extracellular vesicles) can deliver cargo, which is vital for the formation of pre-metastatic niches. sEVs participate in multiple aspects of creating a distant microenvironment to promote tumour invasion, including the secretion of inflammatory molecules, immunosuppression, angiogenesis and enhancement of vascular permeability, as well as regulation of the stromal environment. Here, we discuss the multifaceted mechanisms through which breast cancer-derived sEVs contribute to pre-metastatic niches. In addition, sEVs as biomarkers and antimetastatic therapies are also discussed, particularly their use in transporting exosomal microRNAs. The study of sEVs may provide insight into immunotherapy and targeted therapies for breast cancer, and we also provide an overview of their potential role in antitumour metastasis. Video Abstract The online version contains supplementary material available at 10.1186/s12964-022-00945-w.
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影响因子：
5.5
作者：
Gu P;Sun M;Li L;Yang Y;Jiang Z;Ge Y;Wang W;Mu W;Wang H
通讯作者：
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DOI：
10.1186/s13058-016-0740-2
发表时间：
2016-08-11
期刊：
Breast cancer research : BCR
影响因子：
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