LOW FREQUENCY DEPRESSION OF H WAVE IN NORMAL AND SPINAL MAN
LOW FREQUENCY DEPRESSION OF H WAVE IN NORMAL AND SPINAL MAN
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DOI：
10.1016/0014-4886(66)90039-2
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发表时间：
1966-01-01
影响因子：
5.3
通讯作者：
STUART, D
中科院分区：
文献类型：
--
作者：
ISHIKAWA, K;OTT, K;STUART, D
研究了刺激重复率对完整脊髓损伤患者的 H 波振幅的影响。采用的刺激重复率范围为 1 次冲击/10 秒至 10 次冲击/秒。每个刺激序列包含 25 次重复电击。通过使用平均瞬态计算机和 X-Y 绘图仪获得总响应。在完好无损的受试者中，随着重复刺激速率的增加，H 波的振幅逐渐减小。该频率-幅度系列中的抑郁特征与麻醉动物、断头动物和脊柱动物在受到相同频率范围的重复刺激时单突触反射通路中发生的低频抑郁相似。各种证据表明，人类的 H 波和实验动物的单突触反射中也存在同样的抑郁现象。脊髓损伤患者的 H 波在痉挛减弱的日子里几乎没有表现出低频抑制。在痉挛加剧的日子里，H 波振幅较低，低频抑制明显。这些结果被认为与低频抑郁是由神经元间回路（可能包括伦肖细胞系统）介导的理论相一致。在痉挛减弱的日子里，这些回路会显得不活跃，在痉挛加剧的日子里，这些回路会显得活跃。各种来源的证据都支持这一理论。
The effects of stimulus repetition rate on the H wave amplitude of intact and spinal cord injury patients were studied. Stimulus repetition rates ranging from 1 shock/10 sec to 10 shock/sec were employed. Each stimulus train consisted of 25 repetitive shocks. Summated responses were obtained by use of a computer of average transients and an X-Y plotter. In the intact subject, the H wave displayed a progressive reduction in amplitude at increasing rates of repetitive stimulation. The profile of depression in this frequency-amplitude series was similar to the low frequency depression that occurs in monosynaptic reflex pathways of anesthetized, decapitated and spinal animals when subjected to repetivive stimulation over the same frequency range. A variety of evidence is presented to suggest the same depressive phenomenon is operative in the H wave of man and the monosynaptic reflex of experimental animals. The H wave of spinal cord injury patients displayed virtually no low frequency depression of days of diminished spasticity. On days of heightened spasticity H wave amplitude was low and low frequency depression was evident. These results are thought compatible with the theory that low frequency depression is mediated by interneuronal circuits, including possibly the Renshaw cell system. These circuits would appear hypoactive on days of diminished spasticity and hyperactive on days of heightened spasticity. Evidence from a variety of sources is presented to support this theory.