ENCODE data at the ENCODE portal.
ENCODE data at the ENCODE portal.
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DOI：
10.1093/nar/gkv1160
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发表时间：
2016-01-04
影响因子：
14.9
通讯作者：
Cherry JM
中科院分区：
文献类型：
--
作者：
Sloan CA;Chan ET;Davidson JM;Malladi VS;Strattan JS;Hitz BC;Gabdank I;Narayanan AK;Ho M;Lee BT;Rowe LD;Dreszer TR;Roe G;Podduturi NR;Tanaka F;Hong EL;Cherry JM
DNA元素（编码）项目的百科全书正处于创建人类基因组功能元素的全面目录的第三阶段。该项目的这一阶段包括测量的扩展，这些测定方法测量了不同的RNA群体，鉴定与RNA和DNA相互作用的蛋白质，DNA超敏反应的探针区域以及在广泛的细胞和组织类型中的DNA甲基化水平，以识别推定的调节性调节性调节性。元素。迄今为止，科学界已经发布了近5000个实验的结果。这些数据可在新的Encode Portal（www.encodeproject.org）上进行搜索，可视化和下载。经过改进的编码门户提供了基于元数据浏览和搜索编码数据的新方法，这些元数据描述了分析的分析以及关注数据出处的分析的摘要。此外，这是一个灵活的平台，允许从多个项目集成基因组数据。该门户经验旨在通过依靠允许实验可重复使用和可重复性的元数据来改善对数据的访问。
The Encyclopedia of DNA Elements (ENCODE) Project is in its third phase of creating a comprehensive catalog of functional elements in the human genome. This phase of the project includes an expansion of assays that measure diverse RNA populations, identify proteins that interact with RNA and DNA, probe regions of DNA hypersensitivity, and measure levels of DNA methylation in a wide range of cell and tissue types to identify putative regulatory elements. To date, results for almost 5000 experiments have been released for use by the scientific community. These data are available for searching, visualization and download at the new ENCODE Portal (www.encodeproject.org). The revamped ENCODE Portal provides new ways to browse and search the ENCODE data based on the metadata that describe the assays as well as summaries of the assays that focus on data provenance. In addition, it is a flexible platform that allows integration of genomic data from multiple projects. The portal experience was designed to improve access to ENCODE data by relying on metadata that allow reusability and reproducibility of the experiments.