OpenDose: Open-Access Resource for Nuclear Medicine Dosimetry
OpenDose: Open-Access Resource for Nuclear Medicine Dosimetry
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DOI：
10.2967/jnumed.119.240366
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发表时间：
2020-10-01
影响因子：
9.3
通讯作者：
Bardies, Manuel
中科院分区：
文献类型：
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作者：
Chauvin, Maxime;Borys, Damian;Bardies, Manuel
放射性药物剂量测定取决于放射源在空间和时间上的定位，并且需要估计由沉积在目标内的源发射的能量的量。特别是，当计算资源不可访问时，可以使用基于剂量测定模型的特定吸收分数（SAF）或S值的预先计算的表来执行该任务。OpenDose合作的目的是生成并免费提供一系列剂量测定数据和工具。研究方法：OpenDose汇集了来自18个国际团队的资源和专业知识，使用辐射传输中最受欢迎的6种蒙特卡罗代码（EGSnrc/EGS++，FLUKA，GATE，Geant 4，MCNP/MCNPX和PENDIX PE）生成和比较可追溯的剂量测定数据。将SAF及其相关的统计不确定性上传到关系数据库中。然后根据国际放射防护委员会出版物107中提供的放射性同位素衰变数据，从单能SAF计算S值。结果如下：OpenDose协作为2个国际辐射防护委员会出版的110个成人参考模型的所有源区域和目标组合产生了SAF。从不同的蒙特卡罗代码计算的SAF在所有的能量，SD低于个人的统计不确定性，在良好的协议。计算的S值与OLINDA/EXM 2.0（商业）和IDAC-Dose 2.1（免费）软件一致。已经开发了一个专门网站（www.opendose.org），方便和开放地获取所有数据。结论：OpenDose网站允许显示和下载1，252种放射性核素的SAF和相应的S值。OpenDose合作将向新的研究团队开放，将数据生产扩展到其他剂量模型，并实施新的免费功能，如在线剂量工具和患者特定吸收剂量计算软件，以及教育资源。
Radiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources and requires the estimation of the amount of energy emitted by the sources deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables of specific absorbed fractions (SAFs) or S values based on dosimetric models. The aim of the OpenDose collaboration is to generate and make freely available a range of dosimetric data and tools. Methods: OpenDose brings together resources and expertise from 18 international teams to produce and compare traceable dosimetric data using 6 of the most popular Monte Carlo codes in radiation transport (EGSnrc/EGS++, FLUKA, GATE, Geant4, MCNP/MCNPX, and PENELOPE). SAFs are uploaded, together with their associated statistical uncertainties, in a relational database. S values are then calculated from monoenergetic SAFs on the basis of the radioisotope decay data presented in International Commission on Radiological Protection Publication 107. Results: The OpenDose collaboration produced SAFs for all source region and target combinations of the 2 International Commission on Radiological Protection Publication 110 adult reference models. SAFs computed from the different Monte Carlo codes were in good agreement at all energies, with SDs below individual statistical uncertainties. Calculated S values were in good agreement with OLINDA/EXM 2.0 (commercial) and IDAC-Dose 2.1 (free) software. A dedicated website (www.opendose.org) has been developed to provide easy and open access to all data. Conclusion: The OpenDose website allows the display and downloading of SAFs and the corresponding S values for 1,252 radionuclides. The OpenDose collaboration, open to new research teams, will extend data production to other dosimetric models and implement new free features, such as online dosimetric tools and patient-specific absorbed dose calculation software, together with educational resources.