Interhemispheric auditory connectivity requires normal access to sound in both ears during development
Interhemispheric auditory connectivity requires normal access to sound in both ears during development
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DOI：
10.1016/j.neuroimage.2019.116455
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发表时间：
2019-12
期刊：
影响因子：
5.7
通讯作者：
Daniel A. Smieja;B. Dunkley;B. Papsin;Vijayalakshmi Easwar;H. Yamazaki;Michael Deighton;K. Gordon
中科院分区：
文献类型：
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作者：
Daniel A. Smieja;B. Dunkley;B. Papsin;Vijayalakshmi Easwar;H. Yamazaki;Michael Deighton;K. Gordon
尽管早期双侧人工耳蜗植入，先天性耳聋儿童仍不能发展出准确的空间听力；因此，我们想知道这些孩子的大脑听觉网络是否被破坏了。对13例听力正常儿童和16例同时接受双侧人工耳蜗植入的儿童进行单侧和双侧脑电反应。利用时间限制伪影和相干源抑制（TRACS）波束形成器估计皮层活动区域，通过测量源响应之间的相干性来识别皮层连接区域。全脑θ波相干性分析显示，在所有情况下，在早期潜伏期时，颞区之间的联系最强。正常听力儿童双侧听觉皮层的想象连贯性较单侧强，反映了双侧听觉网络的促进作用。在使用人工耳蜗的儿童进行双侧刺激时，发现了相反的效果，即连贯性下降。植入人工耳蜗的儿童在双侧刺激下也表现出独特的听觉网络，其特征是枕叶和额叶区域之间的连通性增加。这些发现表明，用于声音处理的皮质网络通常由双侧输入促进，但在通过两个独立的人工耳蜗植入听力的儿童中被破坏。因此，改善先天性耳聋儿童听力的努力必须包括纠正潜在的双侧输入不匹配，以支持大脑发育。
Despite early bilateral cochlear implantation, children with congenital deafness do not develop accurate spatial hearing; we thus asked whether auditory brain networks are disrupted in these children. EEG responses were evoked unilaterally and bilaterally in 13 children with normal hearing and 16 children receiving bilateral cochlear implants simultaneously. Active cortical areas were estimated by the Time Restricted Artifact and Coherent source Suppression (TRACS) beamformer and connected cortical areas were identified by measuring coherence between source responses. A whole-brain analysis of theta band coherence revealed the strongest connections between the temporal areas in all conditions at early latencies. Stronger imaginary coherence in activity between the two auditory cortices to bilateral than unilateral input was found in children with normal hearing reflecting facilitation in the auditory network during bilateral hearing. The opposite effect, depressed coherence, was found during bilateral stimulation in children using cochlear implants. Children with cochlear implants also showed a unique auditory network in response to bilateral stimulation which was marked by increased connectivity between occipital and frontal areas. These findings suggest that cortical networks for sound processing are normally facilitated by bilateral input but are disrupted in children who hear through two independent cochlear implants. Efforts to improve hearing in children with congenital deafness must thus include corrections to potential mismatches in bilateral input to support brain development.