Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study.
Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study.
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DOI：
10.1210/jcem.84.12.6182
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发表时间：
1999-12
期刊：
影响因子：
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通讯作者：
L. Bachrach;T. Hastie;May‐Choo Wang;B. Narasimhan;R. Marcus
中科院分区：
文献类型：
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作者：
L. Bachrach;T. Hastie;May‐Choo Wang;B. Narasimhan;R. Marcus
在一项对423名健康的亚裔、黑人、西班牙裔和白人男性和女性(9-25岁)进行的纵向研究中，研究了种族和性别在骨矿获取方面的差异。用双能X射线骨密度仪每年测量脊柱、股骨颈、全髋关节和全身的骨量，最长持续4年。比较4个民族按年龄调整的平均面骨密度(BMD)和体积骨密度(BMAD)曲线。仅在黑人和非黑人受试者之间观察到面积和体积骨密度的一致性差异。在女性中，黑人在所有骨骼部位的BMD和BMAD的平均水平更高。亚洲人、西班牙裔和白人女性股骨颈BMD、全身BMD和全身骨矿含量/身高比值差异显著，亚洲人股骨颈BMAD显著低于西班牙裔女性。和女性一样，黑人男性在所有BMD和BMAD测量中的平均值始终高于非黑人。在非黑人男性受试者中也观察到了一些差异。白人的平均总髋部骨密度、全身骨密度和全身骨矿含量/身高比高于亚洲和西班牙裔男性；西班牙裔男性脊柱骨密度低于白人和亚洲男性。骨密度增加的速度因性别和骨骼部位而异。在女性中，全髋骨密度、脊柱骨密度和全身骨密度分别在14.1、15.7和16.4岁时达到平台期。对于男性来说，骨密度的增长在全髋关节15.7岁和脊柱和全身17.6岁时持平。黑人、亚裔女性和亚裔男性往往比其他种族群体更早达到骨密度平台期。在解释儿科骨密度测量数据时，建议使用特定性别和种族的标准。
Ethnic and gender differences in bone mineral acquisition were examined in a longitudinal study of 423 healthy Asian, black, Hispanic, and white males and females (aged 9-25 yr). Bone mass of the spine, femoral neck, total hip, and whole body was measured annually for up to 4 yr by dual energy x-ray absorptiometry. Age-adjusted mean bone mineral curves for areal (BMD) and volumetric (BMAD) bone mineral density were compared for the 4 ethnic groups. Consistent differences in areal and volumetric bone density were observed only between black and nonblack subjects. Among females, blacks had greater mean levels of BMD and BMAD at all skeletal sites. Differences among Asians, Hispanics, and white females were significant for femoral neck BMD, whole body BMD, and whole body bone mineral content/height ratio, for which Asians had significantly lower values; femoral neck BMAD in Asian and white females was lower than that in Hispanics. Like the females, black males had consistently greater mean values than nonblacks for all BMD and BMAD measurements. A few differences were also observed among nonblack male subjects. Whites had greater mean total hip BMD, whole body BMD, and whole body bone mineral content/height ratio than Asian and Hispanic males; Hispanics had lower spine BMD than white and Asian males. The tempo of gains in BMD varied by gender and skeletal site. In females, total hip, spine, and whole body BMD reached a plateau at 14.1, 15.7, and 16.4 yr, respectively. For males, gains in BMD leveled off at 15.7 yr for total hip and at age 17.6 yr for spine and whole body. Black and Asian females and Asian males tended to reach a plateau in BMD earlier than the other ethnic groups. The use of gender- and ethnic-specific standards is recommended when interpreting pediatric bone densitometry data.