Evolution of a focal brain lesion produced by interlaced microplanar X-rays.
Evolution of a focal brain lesion produced by interlaced microplanar X-rays.
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交错微平面 X 射线产生的局灶性脑损伤的演变。
DOI：
10.1055/s-2007-976514
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Dilmanian,FA
中科院分区：
文献类型：
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作者：
Anschel,DJ;Romanelli,P;Benveniste,H;Foerster,B;Kalef-Ezra,J;Zhong,Z;Dilmanian,FA
立体定向放射外科使中枢神经系统疾病的治疗取得了进展。它依赖于向精确目标提供相对高剂量照射，同时使周围组织暴露于极低剂量的原理。我们描述了一种使用隔行微平面 X 射线的新型放射外科方法，我们将其称为“显微放射外科”。微束的使用可实现比当前临床使用的技术高 1000 倍的精度。为了演示这种新方法，我们在大鼠大脑中产生了约 3.8 mm 3 的损伤。使用 9.4 特斯拉磁共振成像对病变进行了 216 天的跟踪。我们的结果显示交错梁处的病变逐渐发展。病变开始时仅为高 T2 信号，但在 2 个月内发展到包括低 T1 和混合 T2 信号的中心区域。仅暴露于非交错微束的大脑另一侧未观察到病变。交错微束是产生局灶性脑微损伤的有效方法。这项技术可能允许未来通过手术或更传统的放射外科手段治疗无法达到的病理学。
Stereotactic radiosurgery has led to advances in the treatment of central nervous system disease. It relies upon the principle of delivering relatively high dose irradiation to a precise target, while exposing surrounding tissues to extremely low doses. We describe a novel radiosurgical approach using interlaced microplanar X-rays which we have termed “microradiosurgery.” The use of microbeams allows for 1000-times greater precision than current clinically employed techniques. As a demonstration of this new method, we produced a∼ 3.8 mm 3 lesion in the rat brain. The lesion was followed over a period of 216 days using 9.4 Tesla magnetic resonance imaging. Our results show a gradually developing lesion at the site of the interlaced beams. The lesion began as a high T2 signal only, but advanced to include a central area of low T1 and mixed T2 signal within 2 months. No lesion was observed in the other side of the brain which was exposed to non-interlaced microbeams only. Interlaced microbeams is an effective method to create focal brain microlesions. This technique may allow the future treatment of pathology not accessible by surgical or more traditional radiosurgical means.