Brief light stimulation during the mouse nocturnal activity phase simultaneously induces a decline in core temperature and locomotor activity followed by EEG-determined sleep.
Brief light stimulation during the mouse nocturnal activity phase simultaneously induces a decline in core temperature and locomotor activity followed by EEG-determined sleep.
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小鼠夜间活动阶段的短暂光刺激同时诱导核心温度和运动活动下降，随后是脑电图确定的睡眠。
DOI：
10.1152/ajpregu.00460.2012
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Morin,LawrenceP
中科院分区：
文献类型：
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作者：
Studholme,KeithM;Gompf,HeinrichS;Morin,LawrenceP
光对哺乳动物有多种影响。出乎意料的是，这些影响之一是停止夜间运动和诱导行为睡眠（光嗜睡）。在这里，我们以几种方式扩展了最初的观察结果，包括核心体温（Tc）响应于CT 15或CT 18的光刺激而大幅下降（约1.5°C）的基本证明，表明这种变化是对光的直接响应，而不仅仅是运动抑制的结果。结果表明：（1）夜间光刺激后，小鼠的运动和Tc迅速下降，（2）光诱导的运动抑制的幅度和开始时间的变异性很大，而Tc的变异性很小，（3）Tc在运动恢复之前就从光诱导的下降中恢复，（4）光诱导的运动抑制的幅度和开始时间的变异性很大，而Tc的变异性很小。（4）在有载和无载条件下，每天下午晚些时候Tc的增加先于车轮运行的相应增加; 5）在主观夜晚结束时，体温升高的Tc比自发活动持续时间长。最后，EEG测量证实了光诱导睡眠，并且当测量Tcor运动时，显示了它们与睡眠开始的时间关联。基于EEG和不动性的睡眠检测方法都证实了光诱导睡眠的快速诱导。光诱导的运动丧失和Tc下降之间的相似性表明了平行反应的共同原因。光嗜睡反应可能取决于运动和同时低Tc的情况下。
Light exerts a variety of effects on mammals. Unexpectedly, one of these effects is the cessation of nocturnal locomotion and the induction of behavioral sleep (photosomnolence). Here, we extend the initial observations in several ways, including the fundamental demonstration that core body temperature (Tc) drops substantially (about 1.5°C) in response to the light stimulation at CT15 or CT18 in a manner suggesting that the change is a direct response to light rather than simply a result of the locomotor suppression. The results show that1) the decline of locomotion and Tcbegin soon after nocturnal light stimulation;2) the variability in the magnitude and onset of light-induced locomotor suppression is very large, whereas the variability in Tcis very small;3) Tcrecovers from the light-induced decline in advance of the recovery of locomotion;4) under entrained and freerunning conditions, the daily late afternoon Tcincrease occurs in advance of the corresponding increase in wheel running; and5) toward the end of the subjective night, the nocturnally elevated Tcpersists longer than does locomotor activity. Finally, EEG measurements confirm light-induced sleep and, when Tcor locomotion was measured, show their temporal association with sleep onset. Both EEG- and immobility-based sleep detection methods confirm rapid induction of light-induced sleep. The similarities between light-induced loss of locomotion and drop in Tcsuggest a common cause for parallel responses. The photosomnolence response may be contingent upon both the absence of locomotion and a simultaneous low Tc.