The effect of coffee consumption on insulin sensitivity and other biological risk factors for type 2 diabetes: a randomized placebo-controlled trial
The effect of coffee consumption on insulin sensitivity and other biological risk factors for type 2 diabetes: a randomized placebo-controlled trial
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DOI：
10.1093/ajcn/nqz306
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发表时间：
2020-02-01
影响因子：
7.1
通讯作者：
van Dam, Rob M.
中科院分区：
文献类型：
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作者：
Alperet, Derrick Johnston;Rebello, Salome Antonette;van Dam, Rob M.
背景：在观察性研究中，饮用咖啡一直与较低的2型糖尿病风险相关。目的：我们旨在克服先前在随机安慰剂对照试验中进行的咖啡试验对胰岛素敏感性的影响的局限性。方法：我们对126例超重、非胰岛素敏感(HOMA-IR和GT；年龄35-69岁的中国人、马来人和亚裔印度人的男性和女性。参与者被随机分配到每天4杯速溶普通咖啡(n=62)或4杯类似咖啡的安慰剂饮料(n=)。主要结果是使用高胰岛素正血糖钳夹在稳态条件下评估每公斤体重每分钟(MBW)的葡萄糖代谢量。结果：与安慰剂相比，饮用咖啡并没有显著改变胰岛素敏感性(MBW的百分比平均差异=4.0%；95%CI：-8.3，18.0%；P=0.53)。此外，在干预24周后，咖啡组和安慰剂组之间的空腹血糖(2.9%；95%CI：-0.4，6.3%；P=0.09)或胰岛素抵抗的生物介质，如血浆脂联素(2.3%；95%CI：-1.4，6.2%；P=0.22)没有显著差异。喝咖啡的参与者脂肪质量(FM)下降(-3.7%；95%CI：-6.3%，-1.1%；P=0.006)，尿肌酐浓度下降(-21.2%；95%CI：-31.4%，-9.5%；P=0.001)。结论：每天饮用4杯含咖啡因咖啡24周对胰岛素敏感性或胰岛素抵抗的生物介质没有显著影响，但与FM的轻微损失和尿肌酐浓度降低有关。这项试验在Clinicaltrials.gov上注册为NCT01738399。注册日期为2012年11月28日。试验赞助商：雀巢研究公司，瑞士洛桑。试验地点：新加坡国立大学。
Background: In observational studies, coffee consumption has been consistently associated with a lower risk of type 2 diabetes mellitus. Trials examining the effect of coffee consumption on glucose metabolism have been limited by the use of surrogate insulin sensitivity indices, small sample sizes, lack of blinding, and short follow-up duration.Objectives: We aimed to overcome limitations of previously conducted coffee trials in a randomized placebo-controlled trial of the effect of coffee consumption on insulin sensitivity.Methods: We conducted a 24-wk randomized placebo-controlled trial in 126 overweight, non-insulin sensitive (HOMA-IR >= 1.30), Chinese, Malay, and Asian-Indian males and females aged 35-69 y. Participants were randomly assigned to receive 4 cups of instant regular coffee (n = 62) or 4 cups of a coffee-like placebo beverage (n = 64) per day. The primary outcome was the amount of glucose metabolized per kilogram of body weight per minute (Mbw) assessed during steady-state conditions with a hyperinsulinemic euglycemic clamp. Secondary outcomes included other clamp-based insulin sensitivity measures, biological mediators of insulin sensitivity, and measures of fasting glucose metabolism.Results: Coffee consumption did not significantly change insulin sensitivity compared with placebo (percentage mean difference in Mbw = 4.0%; 95% CI: -8.3, 18.0%; P = 0.53). Furthermore, no significant differences in fasting plasma glucose (2.9%; 95% CI: -0.4, 6.3%; P = 0.09) or biological mediators of insulin resistance, such as plasma adiponectin (2.3%; 95% CI: -1.4, 6.2%; P = 0.22), were observed between coffee and placebo groups over 24 wk of intervention. Participants in the coffee arm experienced a loss of fat mass (FM) (-3.7%; 95% CI: -6.3, -1.1%; P = 0.006) and reduction in urinary creatinine concentrations (-21.2%; 95% CI: -31.4,-9.5%; P= 0.001) comparedwith participants in the placebo arm over 24 wk of intervention.Conclusions: Consuming 4 cups/d of caffeinated coffee for 24 wk had no significant effect on insulin sensitivity or biological mediators of insulin resistance but was associated with a modest loss of FM and reduction in urinary creatinine concentrations. This trial was registered at clinicaltrials.gov as NCT01738399. Registered on November 28, 2012. Trial sponsor: Nestle Research, Lausanne, Switzerland. Trial site: National University of Singapore.