Sulfasalazine blocks the development of tactile allodynia in diabetic rats.
Sulfasalazine blocks the development of tactile allodynia in diabetic rats.
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DOI：
10.2337/db07-1274
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发表时间：
2008-10
期刊：
影响因子：
7.7
通讯作者：
Mitchell, Rochanda
中科院分区：
文献类型：
--
作者：
Berti-Mattera, Liliana N.;Kern, Timothy S.;Siegel, Ruth E.;Nemet, Ina;Mitchell, Rochanda
OBJECTIVE—Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception and targets of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pain in diabetes. RESEARCH DESIGN AND METHODS—We examined the effects of sulfasalazine, salicylates, and the poly(ADP-ribose) polymerase-1 inhibitor PJ34 on altered nociception in streptozotocin-induced diabetic rats.我们还评估了接受治疗的动物的坐骨神经和背根神经节（DRG）中柳氮磺吡啶靶标的水平。 Finally, we analyzed the development of tactile allodynia in diabetic mice lacking expression of the sulfasalazine target nuclear factor-κB (NF-κB) p50. RESULTS—Sulfasalazine completely blocked the development of tactile allodynia in diabetic rats, whereas relatively minor effects were observed with other salicylates and PJ34. Along with the behavioral findings, sciatic nerves and DRG from sulfasalazine-treated diabetic rats displayed a decrease in NF-κB p50 expression compared with untreated diabetic animals.重要的是，糖尿病 NF-κB p50−/− 小鼠没有出现触觉异常性疼痛，这支持了 NF-κB 在糖尿病神经病变中的作用。柳氮磺吡啶治疗还增加了糖尿病大鼠坐骨神经中的肌苷水平。 CONCLUSIONS—The complete inhibition of tactile allodynia in experimental diabetes by sulfasalazine may stem from its ability to regulate both NF-κB and inosine.柳氮磺吡啶可能有助于治疗糖尿病患者的伤害性改变。
OBJECTIVE—Diabetic neuropathy is manifested either by loss of nociception (painless syndrome) or by mechanical hyperalgesia and tactile allodynia (pain in response to nonpainful stimuli). While therapies with vasodilators or neurotrophins reverse some functional and metabolic abnormalities in diabetic nerves, they only partially ameliorate neuropathic pain. The reported link between nociception and targets of the anti-inflammatory drug sulfasalazine prompted us to investigate its effect on neuropathic pain in diabetes. RESEARCH DESIGN AND METHODS—We examined the effects of sulfasalazine, salicylates, and the poly(ADP-ribose) polymerase-1 inhibitor PJ34 on altered nociception in streptozotocin-induced diabetic rats. We also evaluated the levels of sulfasalazine targets in sciatic nerves and dorsal root ganglia (DRG) of treated animals. Finally, we analyzed the development of tactile allodynia in diabetic mice lacking expression of the sulfasalazine target nuclear factor-κB (NF-κB) p50. RESULTS—Sulfasalazine completely blocked the development of tactile allodynia in diabetic rats, whereas relatively minor effects were observed with other salicylates and PJ34. Along with the behavioral findings, sciatic nerves and DRG from sulfasalazine-treated diabetic rats displayed a decrease in NF-κB p50 expression compared with untreated diabetic animals. Importantly, the absence of tactile allodynia in diabetic NF-κB p50−/− mice supported a role for NF-κB in diabetic neuropathy. Sulfasalazine treatment also increased inosine levels in sciatic nerves of diabetic rats. CONCLUSIONS—The complete inhibition of tactile allodynia in experimental diabetes by sulfasalazine may stem from its ability to regulate both NF-κB and inosine. Sulfasalazine might be useful in the treatment of nociceptive alterations in diabetic patients.
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影响因子：
15.3
作者：
Brambilla, R;Bracchi-Ricard, V;Hu, WH;Frydel, B;Bramwell, A;Karmally, S;Green, EJ;Bethea, JR
通讯作者：
Bethea, JR
影响因子：
8.2
作者：
Calcutt, NA;Freshwater, JD;Mizisin, AP
通讯作者：
Mizisin, AP
DOI：
10.1073/pnas.96.11.6377
发表时间：
1999-05-25
影响因子：
11.1
作者：
Cronstein, BN;Montesinos, MC;Weissmann, G
通讯作者：
Weissmann, G
影响因子：
8.2
作者：
Li, F;Szabó, C;Obrosova, IG
通讯作者：
Obrosova, IG
影响因子：
25
作者：
Nickols, JC;Valentine, W;Carter, BD
通讯作者：
Carter, BD