Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe
Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe
复制标题
DOI：
10.1016/j.jhep.2011.10.007
复制
发表时间：
2012-03-01
影响因子：
25.7
通讯作者：
Elkashab, Magdy
中科院分区：
文献类型：
--
作者：
Myers, Robert P.;Pomier-Layrargues, Gilles;Elkashab, Magdy
背景和目标：FibroScan XL探头有助于通过瞬时弹性成像（TE）测量肥胖患者的肝脏硬度（LSM），但尚未描述影响其准确性的因素。方法：210例慢性肝病患者（45%为病毒性肝炎，55%为非酒精性脂肪性肝病（NAFLD），体重指数（BMI）>= 28 kg/m2）接受了肝活检，并使用FibroScan XL探头进行了TE检查。通过比较不一致和非不一致病例的患者、TE和活检特征，确定了指标之间不一致≥ 2个纤维化分期的预测因子，发生在11%的患者（n = 24）中。结果：在75%（18/24）的不一致病例中，FibroScan XL探头估计的纤维化大于活检。尽管活检质量与不一致性无关，但不一致病例不太可能有≥ 10次有效注射（75% vs. 97%; p = 0.001），成功率≥ 60%（67% vs. 95%; p
Background & Aims: The FibroScan XL probe facilitates liver stiffness measurement (LSM) by transient elastography (TE) in obese patients, yet factors affecting its accuracy have not been described. Our objectives were to examine the prevalence, risk factors, and causes of discordance between fibrosis estimated by the FibroScan XL probe and biopsy.Methods: Two hundred and ten patients with chronic liver disease (45% viral hepatitis, 55% nonalcoholic fatty liver disease (NAFLD) and a body mass index (BMI) >= 28 kg/m(2)) underwent liver biopsy and TE with the FibroScan XL probe. Predictors of discordance >= 2 fibrosis stages between measures, which occurred in 11% of patients (n = 24), were identified by comparing patient, TE, and biopsy characteristics of discordant and non-discordant cases.Results: Fibrosis estimated by the FibroScan XL probe was greater than biopsy in 75% (18/24) of discordant cases. Although biopsy quality was not associated with discordance, discordant cases were less likely to have >= 10, valid shots (75% vs. 97%; p = 0.001), a success rate >= 60% (67% vs. 95%; p