Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
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克隆鼠淋巴瘤中伴随的 K- 和 N-ras 基因点突变。
DOI：
10.1128/mcb.8.5.2233-2236.1988
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发表时间：
1988
影响因子：
5.3
通讯作者：
Pellicer,A
中科院分区：
文献类型：
--
作者：
Diamond,LE;Guerrero,I;Pellicer,A
我们调查了一组诱发的小鼠淋巴瘤的c-ras基因突变。K-ras基因似乎在我们的系统中优先激活，并且在同一肿瘤中至少有两个伴随K-ras基因和N-ras基因突变的例子。这表明，在某些情况下，额外的ras突变可能有助于肿瘤的发生，是ras激活在肿瘤进展中的作用的证据。
We have surveyed a panel of induced murine lymphomas for c-rasgene mutations. The K-rasgene seems to be preferentially activated in our system, and there are at least two examples of concomitant K- and N-rasgene mutations in the same tumor. This indicates that in some cases additional ras mutations may contribute to tumorigenesis and is evidence for a role ofrasactivation in tumor progression.