Host control of human papillomavirus infection and disease
Host control of human papillomavirus infection and disease
复制标题
DOI：
10.1016/j.bpobgyn.2017.08.001
复制
发表时间：
2018-02-01
影响因子：
5.5
通讯作者：
Doorbar, John
中科院分区：
文献类型：
--
作者：
Doorbar, John
大多数人乳头瘤病毒会引起隐性感染，微妙地影响上皮稳态，以确保基因组在上皮基底层中持续存在。与明显的乳头状瘤一样，这些自限性病变会脱落病毒颗粒，以确保群体水平的维持，并依赖于病毒基因表达、免疫细胞刺激和免疫监视之间的平衡来维持持久性。复杂的免疫逃避策略是高危 HPV 类型的特征，也导致肿瘤形成过程中的病毒基因表达失调。肿瘤发生在特定的上皮部位，在那里发现了脆弱的细胞，例如宫颈转化区的储备细胞或立方细胞。 β乳头瘤病毒感染也会使免疫缺陷的个体容易患上癌症。因此，宿主对 HPV 感染的控制涉及角质形成细胞和适应性免疫反应之间的局部相互作用。有效的免疫检测和监测可限制明显的疾病，从而导致 HPV 作为生产性微病变持续存在或处于真正的潜伏状态。 (C) 2017 年由爱思唯尔有限公司出版。
Most human papillomaviruses cause inapparent infections, subtly affecting epithelial homeostasis, to ensure genome persistence in the epithelial basal layer. As with conspicuous papillomas, these self-limiting lesions shed viral particles to ensure population level maintenance and depend on a balance between viral gene expression, immune cell stimulation and immune surveillance for persistence. The complex immune evasion strategies, characteristic of high-risk HPV types, also allow the deregulated viral gene expression that underlies neoplasia. Neoplasia occurs at particular epithelial sites where vulnerable cells such as the reserve or cuboidal cells of the cervical transformation zone are found. Beta papillomavirus infection can also predispose an individual with immune deficiencies to the development of cancers. The host control of HPV infections thus involves local interactions between keratinocytes and the adaptive immune response. Effective immune detection and surveillance limits overt disease, leading to HPV persistence as productive microlesions or in a true latent state. (C) 2017 Published by Elsevier Ltd.