NLRP3 Inflammasome: A Potential Target in Isoflurane Pretreatment Alleviates Stroke-Induced Retinal Injury in Diabetes.
NLRP3 Inflammasome: A Potential Target in Isoflurane Pretreatment Alleviates Stroke-Induced Retinal Injury in Diabetes.
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NLRP3 炎症小体：异氟烷预处理的潜在靶点可减轻糖尿病中风引起的视网膜损伤
DOI：
10.3389/fncel.2021.697449
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发表时间：
2021
影响因子：
5.3
通讯作者：
Zhang HF
中科院分区：
文献类型：
--
作者：
Lin HB;Lin YH;Zhang JY;Guo WJ;Ovcjak A;You ZJ;Feng ZP;Sun HS;Li FX;Zhang HF
缺血性中风仍然是一种毁灭性的疾病，是全球主要的死亡原因。卒中后视力障碍是一种常见的并发症，可导致视力丧失，严重影响患者的生活质量。虽然缺血性中风的传统特征是流向大脑的血流受阻，但这可能与流向眼睛的血液减少相吻合，导致视网膜缺血并导致视力障碍。糖尿病增加了缺血性卒中的风险，并导致糖尿病视网膜病变，后者可能对缺血性视网膜损伤更敏感。在糖尿病状态下，卒中所致视网膜损伤的潜在机制尚未完全阐明。NLRP3(NLRP3)是一种重要的炎症激活因子，在脑缺血和视网膜缺血中可能在催化和形成某些促炎细胞因子中发挥重要作用。异氟醚已被证明可以抑制NLRP3炎症体的激活，并显示出神经保护作用。在本研究中，我们建立了糖尿病小鼠模型，并进行了大脑中动脉闭塞手术，以诱导缺血性卒中。我们的结果显示脑缺血导致糖尿病模型的视网膜损伤。异氟醚预处理可减轻缺血性卒中后的脑和视网膜损伤。值得注意的是，异氟醚预处理抑制了视网膜中NLRP3炎性小体的激活，表明异氟醚预处理可能在糖尿病视网膜损伤中对卒中后视网膜起到保护作用。
Ischemic stroke remains a devastating disease which is the leading cause of death worldwide. Visual impairment after stroke is a common complication which may lead to vision loss, greatly impacting life quality of patients. While ischemic stroke is traditionally characterized by a blockage of blood flow to the brain, this may coincide with reduced blood flow to the eye, resulting in retinal ischemia and leading to visual impairment. Diabetes increases the risk of ischemic stroke and induces diabetic retinopathy; the latter may be more sensitive to the ischemic retinal injury. In diabetic status, the underlying mechanism in stroke-induced retinal injury has not been fully clarified. The NLR pyrin domain containing 3 (NLRP3) inflammasome is an important activator of inflammation, which may play a critical role in catalyzing and forming certain pro-inflammatory cytokines in both cerebral and retinal ischemia. Isoflurane has been demonstrated to inhibit the activation of the NLRP3 inflammasome and show neuroprotective effects. In this study, we established a diabetic mouse model and performed the middle cerebral artery occlusion procedure to induce ischemic stroke. Our results revealed that cerebral ischemia-induced retinal injury in the diabetic model. Isoflurane pretreatment alleviated the cerebral and retinal injury after ischemic stroke. Of note, isoflurane pretreatment inhibited the NLRP3 inflammasome activation in the retina, indicating that isoflurane pretreatment may provide substantial retinal protection in stroke-induced retinal injury in diabetes.
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影响因子：
5.3
作者：
Allen, Rachael S.;Sayeed, Iqbal;Cale, Heather A.;Morrison, Katherine C.;Boatright, Jeffrey H.;Pardue, Machelle T.;Stein, Donald G.
通讯作者：
Stein, Donald G.
影响因子：
--
作者：
Rowe FJ;Wright D;Brand D;Jackson C;Harrison S;Maan T;Scott C;Vogwell L;Peel S;Akerman N;Dodridge C;Howard C;Shipman T;Sperring U;Macdiarmid S;Freeman C
通讯作者：
Freeman C
糖尿病小鼠模型中缺血性中风后巨噬细胞-NLRP3炎症小体激活加剧心脏功能障碍
影响因子：
5.6
作者：
Lin, Hong-Bin;Wei, Guan-Shan;Zhang, Hong-Fei
通讯作者：
Zhang, Hong-Fei
影响因子：
9.1
作者：
Liu Jin;Yeung, Patrick Ka Kit;Chung, Sookja Kim
通讯作者：
Chung, Sookja Kim
影响因子：
7.3
作者：
Forrester JV;Kuffova L;Delibegovic M
通讯作者：
Delibegovic M