Feo - Transport of ferrous iron into bacteria
Feo - Transport of ferrous iron into bacteria
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DOI：
10.1007/s10534-006-0003-2
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发表时间：
2006-04-01
期刊：
影响因子：
3.5
通讯作者：
Andrews, Simon C.
中科院分区：
文献类型：
--
作者：
Cartron, Michael L.;Maddocks, Sarah;Andrews, Simon C.
细菌通常利用一种独特的转运蛋白，称为FeO，专门从环境中获取亚铁（Fe 2+）形式的铁。肠细菌FeO系统由三种蛋白质组成：FeoA，一种可能位于胞质溶胶中的小的可溶性SH 3结构域蛋白; FeoB，一种具有胞质N-末端G蛋白结构域和C-末端完整内膜结构域的大蛋白，该结构域含有两个“Gate”基序，可能用作Fe 2+通透酶; FeoC，一种显然用作[Fe-S]依赖性转录抑制因子的小蛋白。我们提供了一个审查目前的文献结合细菌FeO系统的生物信息学评估，显示它们如何表现出共同的特点，以及组织和组成的差异，这可能反映了所采用的机制和功能的变化。
Bacteria commonly utilise a unique type of transporter, called Feo, to specifically acquire the ferrous (Fe2+) form of iron from their environment. Enterobacterial Feo systems are composed of three proteins: FeoA, a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. We provide a review of the current literature combined with a bioinformatic assessment of bacterial Feo systems showing how they exhibit common features, as well as differences in organisation and composition which probably reflect variations in mechanisms employed and function.