Self-avoidance and Tiling: Mechanisms of Dendrite and Axon Spacing
Self-avoidance and Tiling: Mechanisms of Dendrite and Axon Spacing
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DOI：
10.1101/cshperspect.a001750
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发表时间：
2010-09-01
影响因子：
7.2
通讯作者：
Sagasti, Alvaro
中科院分区：
文献类型：
--
作者：
Grueber, Wesley B.;Sagasti, Alvaro
轴突或树枝内分支的空间分布以及相邻树枝相互之间的相对排列影响神经元的潜在连通性。尽管乔木可以采用不同的分枝模式来适应它们的功能，但均匀分布的分枝避免聚集或重叠是许多轴突和树枝的共同特征。支配一个表面的相邻乔木之间的重叠程度也是特定神经元类型的特征。一些神经元群体的乔木以一种全面的、不重叠的“瓦片”排列来支配目标，而另一些神经元群体的乔木则显示出大量的领土重叠。本文主要从细胞和分子水平对乔木内和乔木间轴突分支的空间分布调控进行了综述。这些研究揭示了支配脊椎动物和无脊椎动物树突和轴突中树枝排列的原理。控制姐妹枝和相邻乔木空间格局的不同分子机制已经开始被阐明。
The spatial pattern of branches within axonal or dendritic arbors and the relative arrangement of neighboring arbors with respect to one another impact a neuron's potential connectivity. Although arbors can adopt diverse branching patterns to suit their functions, evenly spread branches that avoid clumping or overlap are a common feature of many axonal and dendritic arbors. The degree of overlap between neighboring arbors innervating a surface is also characteristic within particular neuron types. The arbors of some populations of neurons innervate a target with a comprehensive and nonoverlapping "tiled" arrangement, whereas those of others show substantial territory overlap. This review focuses on cellular and molecular studies that have provided insight into the regulation of spatial arrangements of neurite branches within and between arbors. These studies have revealed principles that govern arbor arrangements in dendrites and axons in both vertebrates and invertebrates. Diverse molecular mechanisms controlling the spatial patterning of sister branches and neighboring arbors have begun to be elucidated.