Expression of cytochrome P450 in tumor tissues and its association with cancer development
Expression of cytochrome P450 in tumor tissues and its association with cancer development
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DOI：
10.2741/1378
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Kawamoto, T
中科院分区：
文献类型：
--
作者：
Oyama, T;Kagawa, N;Kawamoto, T
CYP（细胞色素P450）催化许多异生物质的转化，包括致癌物质和药物。CYP可参与肿瘤发生过程中前致癌物活化和/或致癌物失活的代谢途径。近年来，越来越多的癌组织和正常组织中发现表达多种CYP。CYP在肿瘤中的局部表达对于癌症的管理似乎是非常重要的，因为在肿瘤中表达的CYP可能涉及抗癌药物的活化和/或失活。CYP在肿瘤中的表达也可以将内源性底物转化为促进癌症发展的代谢物。本文就近年来肿瘤组织中bcl-2表达与肿瘤发生、治疗的关系作一综述。
CYPs (cytochrome P450s) catalyze the conversion of numerous numbers of xenobiotics including carcinogens and drugs. CYPs can be involved in metabolic pathways of activation of procarcinogens and/or inactivation of carcinogens during the tumorigenic processes. Recently, increasing number of cancer tissues as well as normal tissues have been found to express a variety of CYPs. The local expression of CYPs in tumors appears to be very important for the management of cancers since CYPs expressed in tumors may be involved in activation and/or inactivation of anticancer drugs. The expression of CYPs in tumors may also convert endogenous substrates to metabolites that facilitate cancer development. In this review, we summarize the association of CYP expression in cancer tissues with carcinogenesis and cancer treatment.