Comparison of medial preoptic, amygdala, and nucleus accumbens lesions on parental behavior in California mice (Peromyscus californicus)
Comparison of medial preoptic, amygdala, and nucleus accumbens lesions on parental behavior in California mice (Peromyscus californicus)
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DOI：
10.1016/j.physbeh.2007.05.008
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发表时间：
2007-11-23
影响因子：
2.9
通讯作者：
Brown, Richard E.
中科院分区：
文献类型：
--
作者：
Lee, Anna W.;Brown, Richard E.
我们以前已经表明，内侧视前区（MPOA）病变破坏父母的行为在雄性和雌性加州小鼠（P. californicus）。在本研究中，我们比较的影响，在MPOA的病变，在基底外侧杏仁核（BA）和丘脑核（NA）对男性和女性的双亲加州小鼠的父母的行为。对每对雄性-雌性配对中的一只雄性或经产雌性在MPOA、BA或NA中进行电解或假损伤，并测试其亲代反应性。由于雌性加利福尼亚州P显示产后发情，它们可能在父母测试期间怀孕。MPOA病变产生赤字的男性和女性的父母的行为，和BA病变破坏男性，并在较小程度上，女性的父母的行为。NA病变产生轻微的影响，小狗检索男性和女性的父母的行为没有影响。然而，NA病变不完全破坏的NA壳，该地区最相关的母亲的行为在大鼠，并应进一步调查。这些结果支持的MPOA和BA在男性和女性的父母行为的作用。(C)2007年爱思唯尔公司All rights reserved.
We have previously shown that medial preoptic area (MPOA) lesions disrupt parental behavior in both male and female California mice (P. californicus). In the present study, we compare the effects of lesions in the MPOA, with those in the basolateral amygdala (BA) and nucleus accumbens (NA) on male and female parental behaviors in the biparental California mouse. A male or multiparous female from each male-female pair was given an electrolytic or sham lesion in the MPOA, BA, or NA and tested for parental responsiveness. Since female P californicus show postpartum estrus, they were likely pregnant during parental testing. MPOA lesions produced deficits in both male and female parental behaviors, and BA lesions disrupted male, and to a lesser extent, female parental behavior. NA lesions produced mild effects on pup-retrieval in males and no effect on parental behavior in females. However, NA lesions incompletely destroyed the NA shell, the region most relevant for maternal behavior in rats, and should be investigated further. These results support a role for the MPOA and BA in both male and female parental behaviors. (C) 2007 Elsevier Inc. All rights reserved.