The roles of PIKE in tumorigenesis.
The roles of PIKE in tumorigenesis.
复制标题
DOI：
10.1038/aps.2013.71
复制
发表时间：
2013-08
影响因子：
8.2
通讯作者：
Ye, Keqiang
中科院分区：
文献类型：
--
作者：
Qi, Qi;Ye, Keqiang
肿瘤发生是正常细胞进化出逃避和克服通常对其生长和存活的限制的能力的过程。为了确保器官和组织的完整性，细胞增殖和细胞死亡的平衡得到了严格的维持。控制这种平衡的蛋白质要么被认为是促进肿瘤发生的癌基因，要么被认为是防止肿瘤发生的肿瘤抑制因子。磷酸肌醇3激酶增强子（PIKE）是一类具有抗凋亡功能的GTP结合蛋白，在中枢神经系统中发挥重要作用。值得注意的是，越来越多的证据表明PIKE是一种参与肿瘤进展的原癌基因。PIKE基因（CENTG1）在多种人类癌症中扩增，导致抗凋亡和增强侵袭。本文就PIKE蛋白在肿瘤发生中的作用及其在肿瘤治疗中的应用作一综述。
Tumorigenesis is the process by which normal cells evolve the capacity to evade and overcome the constraints usually placed upon their growth and survival. To ensure the integrity of organs and tissues, the balance of cell proliferation and cell death is tightly maintained. The proteins controlling this balance are either considered oncogenes, which promote tumorigenesis, or tumor suppressors, which prevent tumorigenesis. Phosphoinositide 3-kinase enhancer (PIKE) is a family of GTP-binding proteins that possess anti-apoptotic functions and play an important role in the central nervous system. Notably, accumulating evidence suggests that PIKE is a proto-oncogene involved in tumor progression. The PIKE gene (CENTG1) is amplified in a variety of human cancers, leading to the resistance against apoptosis and the enhancement of invasion. In this review, we will summarize the functions of PIKE proteins in tumorigenesis and discuss their potential implications in cancer therapy.
登录
查看更多内容
影响因子：
3.7
作者：
Cerami E;Demir E;Schultz N;Taylor BS;Sander C
通讯作者：
Sander C
影响因子：
30.8
作者：
BIANCHI, AB;HARA, T;KLEY, N
通讯作者：
KLEY, N
影响因子：
7.7
作者：
Chan CB;Liu X;Jung DY;Jun JY;Luo HR;Kim JK;Ye K
通讯作者：
Ye K
影响因子：
7.7
作者：
Chan, Chi Bun;Liu, Xia;Ye, Keqiang
通讯作者：
Ye, Keqiang
影响因子：
11.4
作者：
Chan, Chi-Bun;Liu, Xia;Ye, Keqiang
通讯作者：
Ye, Keqiang