Characterization of regional pulmonary mechanics from serial magnetic resonance imaging data
Characterization of regional pulmonary mechanics from serial magnetic resonance imaging data
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DOI：
10.1016/s1076-6332(03)00329-5
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发表时间：
2003-10-01
影响因子：
4.8
通讯作者：
Hatabu, H
中科院分区：
文献类型：
--
作者：
Gee, J;Sundaram, T;Hatabu, H
理由和目标。本研究的目的是探讨一种方法，用于量化肺运动的连续图像在序列磁共振成像采集在正常呼吸过程中的注册。材料和方法。通过对连续采集的肺图像上的归一化互相关求和以识别图像之间的对应位置来获得肺运动的估计。估计的运动被建模为弹性体的变形，从而反映了肺实质的真实物理行为的一阶近似。从计算的运动场导出的拉格朗日应变被用于量化在连续采集期间在肺中引起的组织变形。该方法在磁共振成像研究中进行了验证，其中在呼吸周期的不同阶段采集了健康志愿者的屏气图像。局部肺实质应变主要集中在肺门，在呼气相的中段应变最大。在体内磁共振成像定量肺运动的潜力，提供了一个新的诊断层面的肺功能的评估，增加了通气和灌注的研究所提供的信息。
Rationale and Objectives. The aim of this study was to investigate a method for quantifying lung motion from the registration of successive images in serial magnetic resonance imaging acquisitions during normal respiration.Materials and Methods. Estimates of pulmonary motion were obtained by summing the normalized cross-correlation over serially acquired lung images to identify corresponding locations between the images. The estimated motions were modeled as deformations of an elastic body and thus reflect to a first order approximation the true physical behavior of lung parenchyma. The Lagrangian strain, derived from the calculated motion fields, were used to quantify the tissue deformation induced in the lung over the serial acquisition.Results. The method was validated on a magnetic resonance imaging study, for which breath-hold images were acquired of a healthy volunteer at different phases of the respiratory cycle. Regional parenchymal strain was observed to be oriented toward the pulmonary hilum, with strain magnitude maximal at the midcycle of the expiratory phase.Conclusion. In vivo magnetic resonance imaging quantification of lung motion holds the potential of providing a new diagnostic dimension in the assessment of pulmonary function, augmenting the information provided by studies of ventilation and perfusion.