Adaptive evolution of formyl peptide receptors in mammals.
Adaptive evolution of formyl peptide receptors in mammals.
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哺乳动物甲酰基肽受体的适应性进化。
DOI：
10.1111/scd.12105
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ueda H
中科院分区：
文献类型：
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作者：
Muto Y;Guindon S;Umemura T;Kőhidai L;Ueda H
口腔干燥症是一种常见疾病，可影响生活质量。服用毛果芸香碱片可以缓解口干症状，但产生许多不良反应。我们调查了毛果芸香碱漱口水的安全性和有效性。MethodsForty老年患者随机分为毛果芸香碱漱口水或水冲洗（对照）组。治疗前和治疗后1个月分别采用视觉模拟评分法（VAS）评分和刺激唾液流率评价疗效。患者记录所有不良反应。结果在毛果芸香碱组，我们评估了24例患者的安全性和19例患者的疗效。在水冲洗组中，我们评估了14例患者的安全性和有效性。毛果芸香碱漱口液治疗后VAS评分明显降低（70 ± 12.9 ~ 47.9 ± 13.1，p < 0.05）。在毛果芸香碱组中观察到47%的总体改善，而对照组为14%（p< 0.05）。毛果芸香碱漱口水治疗后刺激唾液流速显著增加（0.71 ± 0.14至0.83 ± 0.12 mL/min，p< 0.05）。24例患者中有5例报告了毛果芸香碱漱口水使用后的副作用，主要限于口腔不适。ConclusionsPilocarpine漱口水缓解口干症状，改善唾液分泌，副作用轻微。
ObjectiveXerostomia is a common condition and can impair quality of life. Pilocarpine tablet ingestion can relieve dry mouth symptoms, but produces numerous adverse effects. We investigated the safety and efficacy of pilocarpine mouthwash.MethodsForty elderly patients were randomly divided into a pilocarpine mouthwash or water rinse (control) group. Outcomes were assessed by visual analog scale (VAS) scores and stimulated salivary flow rate before and 1 month after treatment. Patients recorded all adverse effects.ResultsIn the pilocarpine group, we evaluated safety in 24 patients and efficacy in 19 patients. In the water rinse group, we evaluated safety and efficacy in 14 patients. VAS scores were significantly reduced after pilocarpine mouthwash treatment (70 ± 12.9 to 47.9 ± 13.1,p< 0.05). Overall improvement was observed in 47% of the pilocarpine group compared to 14% of the controls (p< 0.05). Stimulated salivary flow rate significantly increased (0.71 ± 0.14 to 0.83 ± 0.12 mL/minute,p< 0.05) after pilocarpine mouthwash treatment. Five of 24 patients reported side effects after pilocarpine mouthwash use, predominantly limited to oral discomfort.ConclusionsPilocarpine mouthwash relieved dry mouth symptoms and improved saliva production with minor side effects.