Toxicity, mechanism and health effects of some heavy metals.
Toxicity, mechanism and health effects of some heavy metals.
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一些重金属的毒性，机制和健康影响。
DOI：
10.2478/intox-2014-0009
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发表时间：
2014-06
影响因子：
--
通讯作者：
Beeregowda KN
中科院分区：
文献类型：
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作者：
Jaishankar M;Tseten T;Anbalagan N;Mathew BB;Beeregowda KN
重金属毒性已被证明是一个主要威胁，并与其相关的几个健康风险。这些金属的毒性作用，即使它们没有任何生物作用，仍然以某种形式存在，对人体及其正常功能有害。它们有时充当身体的一个假元素，而在某些时候甚至可能干扰新陈代谢过程。很少有金属，如铝，可以通过排泄活动被清除，而一些金属在体内和食物链中积累，表现出慢性的性质。已经采取了各种公共卫生措施来控制、预防和处理在不同水平上发生的金属毒性，如职业暴露、事故和环境因素。金属毒性取决于吸收剂量、暴露途径和暴露持续时间，即急性或慢性。这可能会导致各种疾病，也可能会由于自由基形成引起的氧化应激而导致过度损害。该综述详细介绍了一些重金属及其毒性机制，以及它们对健康的影响。
Heavy metal toxicity has proven to be a major threat and there are several health risks associated with it. The toxic effects of these metals, even though they do not have any biological role, remain present in some or the other form harmful for the human body and its proper functioning. They sometimes act as a pseudo element of the body while at certain times they may even interfere with metabolic processes. Few metals, such as aluminium, can be removed through elimination activities, while some metals get accumulated in the body and food chain, exhibiting a chronic nature. Various public health measures have been undertaken to control, prevent and treat metal toxicity occurring at various levels, such as occupational exposure, accidents and environmental factors. Metal toxicity depends upon the absorbed dose, the route of exposure and duration of exposure, i.e. acute or chronic. This can lead to various disorders and can also result in excessive damage due to oxidative stress induced by free radical formation. This review gives details about some heavy metals and their toxicity mechanisms, along with their health effects.