Family patterns of developmental dyslexia, part II: behavioral phenotypes.
Family patterns of developmental dyslexia, part II: behavioral phenotypes.
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发育性阅读障碍的家庭模式，第二部分：行为表型。
DOI：
10.1002/ajmg.1320600604
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Bedrosian,M
中科院分区：
文献类型：
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作者：
Wolff,PH;Melngailis,I;Obregon,M;Bedrosian,M
对来自至少有 2 名诵读困难家庭成员的家庭的一级亲属与先证者是唯一受影响的家庭成员的家庭之间的双手协调和运动言语的运动控制进行了比较。一半受影响的亲属有运动协调缺陷；他们来自先证者也表现出运动协调受损的家庭。相比之下，没有运动缺陷的受影响亲属来自先证者没有运动缺陷的阅读障碍家庭。与仅父母一方受影响的家庭中受影响的后代相比，双亲均受影响的家庭中受影响的后代更常见且更严重。然而，当父母双方都受到影响时，运动协调缺陷在受影响的父母中也比只有一方受影响的家庭中受影响的父母更常见和更严重。我们得出的结论是，运动动作的时间分辨率受损确定了发展性阅读障碍某些亚型的行为表型。在大约一半的阅读障碍家族中观察到的运动缺陷和阅读障碍的传播模式与阅读障碍的遗传模型最为一致，其中两个共显性主要基因在先证者也存在运动障碍的阅读障碍谱系中共分离。 © 1995 Wiley-Liss, Inc.
The motor control of bimanual coordination and motor speech was compared between first degree relatives from families with at least 2 dyslexic family members, and families where probands were the only affected family members. Half of affected relatives had motor coordination deficits; and they came from families in which probands also showed impaired motor coordination. By contrast, affected relatives without motor deficits came from dyslexia families where probands did not have motor deficits. Motor coordination deficits were more common and more severe among affected offspring in families where both parents were affected than among affected offspring in families where only one parent was affected. However, motor coordination deficits were also more common and more severe in affectedparentswhen both parents were affected than among affected parents in families where only one parent was affected.We conclude that impaired temporal resolution in motor action identifies a behavioral phenotype in some subtypes of developmental dyslexia. The observed pattern of transmission for motor deficits and reading impairment in about half of dyslexia families was most congruent with a genetic model of dyslexia in which 2 codominant major genes cosegregate in dyslexia pedigrees where the proband is also motorically impaired. © 1995 Wiley‐Liss, Inc.