Immunocytochemical studies of cells in the rat adenohypophysis containing both ACTH and FSH
Immunocytochemical studies of cells in the rat adenohypophysis containing both ACTH and FSH
复制标题
含有 ACTH 和 FSH 的大鼠腺垂体细胞的免疫细胞化学研究
作者：
G. C. Moriarty;L. L. Garner
Siperstein等人的研究1、2首次描述了大鼠腺垂体中促肾上腺皮质激素（ACTH）细胞的细胞学。该细胞呈星状，含有平均直径为220 µm的外周组织颗粒。他们的细胞学工作在我们实验室后来的免疫细胞化学研究中得到了证实3 -5，其中ACTH定位于这种类型细胞的分泌颗粒中。然而，在我们最近对促卵泡激素（FSH）细胞的免疫细胞化学研究中，在一种类似于ACTH细胞的细胞中发现了FSH。我们将这种细胞称为III型促性腺激素细胞6，7。在这里，我们描述的研究旨在测试FSH在这种细胞类型中的反应的特异性，以及III型促性腺激素细胞和含有ACTH的细胞之间的关系。
STUDIES by Siperstein et al.1,2 first described the cytology of the adrenocorticotropin (ACTH) cell in the rat adenohypophysis. This cell is stellate and contains peripherally organised granules averaging 220 µm in diameter. Their cytological work was confirmed in later immunocyto-chemical studies in our laboratory3–5, in which ACTH was localised in the secretory granules of cells of this type. In our recent immunocytochemical studies of follicle-stimulating hormone (FSH) cells, however, FSH was found in a cell which resembled the ACTH cell. We termed this cell the Type III gonadotroph6,7. Here we describe studies designed to test the specificity of the reaction for FSH in this cell type, and the relationship between the Type III gonadotroph and the cell containing ACTH.